National healthcare is driven by the burden of chronic illnesses, and most of these diseases are metabolic in nature, therefore, due to malnutrition. "The reality is when you look at most chronic diseases, they have a underlying metabolic impairment as part of their pathophysiology or pathogenesis" (Professor Jeff Volek, PhD, The Ohio State University). That impairment is insulin resistance. "Virtually every chronic disease has some connection to insulin resistance, where the insulin resistance is either explicitly causing the problem or it's exacerbating it or accelerating the problem" (Professor Benjamin Bikman, PhD, BYU). Proper human nutrition requires animal sourced foods, and sustainable food systems require livestock.

Flourishing requires Nourishing.

Full Talk https://youtu.be/MXokgksI-CM

It is a somewhat common question to me: how do we write C in curl to make it safe and secure for billions of installations? Some precautions we take and decisions we make. There is no silver bullet, just guidelines. As I think you can see for yourself below they are also neither strange nor surprising.

The ‘c’ in curl does not and never did stand for the C programming language, it stands for client. ...

This is a excellent read, and If you work on a multi-person project, I highly recommend going through it.

Eddie Hall, nicknamed "The Beast," is a British former professional strongman born in 1988 in Stoke-on-Trent, England. He rose to global prominence in 2017 when he became the first person to deadlift 500kg (1,102lbs) under official competition conditions, winning the World's Strongest Man title that same year.

Before his strongman career, Hall was a national champion swimmer in his youth. He later worked as a mechanic while developing his strength training. At his competitive peak, he weighed around 400 pounds and consumed up to 12,000 calories daily.

After retiring from strongman competition in 2017, Hall transformed his physique, losing significant weight while maintaining strength. He's ventured into boxing, acting, and television, appearing in shows like "The Strongest Man in History" and several documentaries. He remains a popular figure in strength sports through his YouTube channel and other media appearances.

The instances being used are

• lemmy.doesnotexist.club
• chinese.lol

Here is an example of the coordinated downvoting https://hackertalks.com/post/8692093

Of course its a controversial user who got someone angry enough to automated downvoting @[email protected]

But you can see every post they make gets 53ish downvotes from these two instances, plus some organic ones after a few hours.

Current downvoting Accounts

A individual user airing their personal biases and manipulating lemmy isn't good for the community, regardless of how you feel about their target. This is a really bad thing (tm)

TLDR - If you are a ketogenic lean mass hyper responder with high LDL, insist on imaging to determine your atherosclerotic risk, as this study indicates the LDL and ApoB by itself doesn't indicate a growth in plaque.

Background - Changes in low-density lipoprotein cholesterol (LDL-C) among people following a ketogenic diet (KD) are heterogeneous. Prior work has identified an inverse association between body mass index and change in LDL-C. However, the cardiovascular disease risk implications of these lipid changes remain unknown.

Objectives - The aim of the study was to examine the association between plaque progression and its predicting factors.

Methods - One hundred individuals exhibiting KD-induced LDL-C ≥190 mg/dL, high-density lipoprotein cholesterol ≥60 mg/dL, and triglycerides ≤80 mg/dL were followed for 1 year using coronary artery calcium and coronary computed tomography angiography. Plaque progression predictors were assessed with linear regression and Bayes factors. Diet adherence and baseline cardiovascular disease risk sensitivity analyses were performed.

Results - High apolipoprotein B (ApoB) (median 178 mg/dL, Q1-Q3: 149-214 mg/dL) and LDL-C (median 237 mg/dL, Q1-Q3: 202-308 mg/dL) with low total plaque score (TPS) (median 0, Q1-Q3: 0-2.25) were observed at baseline. Neither change in ApoB (median 3 mg/dL, Q1-Q3: −17 to 35), baseline ApoB, nor total LDL-C exposure (median 1,302 days, Q1-Q3: 984-1,754 days) were associated with the change in noncalcified plaque volume (NCPV) or TPS. Bayesian inference calculations were between 6 and 10 times more supportive of the null hypothesis (no association between ApoB and plaque progression) than of the alternative hypothesis. All baseline plaque metrics (coronary artery calcium, NCPV, total plaque score, and percent atheroma volume) were strongly associated with the change in NCPV.

Conclusions - In lean metabolically healthy people on KD, neither total exposure nor changes in baseline levels of ApoB and LDL-C were associated with changes in plaque. Conversely, baseline plaque was associated with plaque progression, supporting the notion that, in this population, plaque begets plaque but ApoB does not. (Diet-induced Elevations in LDL-C and Progression of Atherosclerosis [Keto-CTA]

Full Paper: https://doi.org/10.1016/j.jacadv.2025.101686

A really excellent film, that deserves thought and reflection

Jared Bauer does a excellent breakdown : 8 years later, i finally understand get out https://youtu.be/NW38mJ1DqPE

Summary

In this episode of the KetoPro Podcast, Richard Smith welcomes back Professor Tim Noakes to discuss the impact of low carbohydrate diets on athletic performance. They explore recent research findings that challenge traditional beliefs about carbohydrates and muscle glycogen, emphasizing the importance of blood glucose levels during endurance activities. The conversation also addresses the adaptation process for athletes transitioning to low carb diets, the health implications of dietary choices for athletes, and the evolving landscape of sports nutrition. In this conversation, the speakers delve into the implications of carbohydrate consumption on athletic performance and overall health. They discuss the hidden dangers of high carbohydrate diets, the efficiency of fat as a fuel source, and the body's macronutrient needs. Personal experiences with zero carb diets are shared, along with insights into the future of research in this area. The conversation also touches on the addiction to carbohydrates among athletes and the genetic factors influencing performance. Ultimately, the speakers advocate for a shift in dietary practices to enhance health and athletic longevity.

Takeaways

• The low carb diet is gaining traction in various sports.
• Carbohydrates can enhance performance, but only during prolonged exercise.
• Muscle glycogen depletion is not as critical as previously thought.
• A small amount of glucose can improve endurance performance.
• Blood glucose levels play a significant role in athletic performance.
• Many studies fail to account for adaptation periods in low carb diets.
• Elite athletes may not always be the best model for dietary studies.
• Health concerns are rising among athletes consuming high carb diets.
• The shift towards low carb diets in sports is inevitable.
• Individual performance improvements matter more than comparisons with elite athletes. High carbohydrate diets can lead to insulin resistance.
• Fat can provide the majority of energy needed for endurance sports.
• The human body is capable of burning fat efficiently.
• Glucose is essential for brain function during exercise.
• Zero carb diets can lead to improved athletic performance.
• Athletes often consume excessive carbohydrates unnecessarily.
• Genetics play a significant role in athletic performance.
• Addiction to sugars is prevalent among athletes.
• Long-term health benefits from a low-carb lifestyle are significant.
• Research on zero carb athletes is needed to understand their performance.

Chapters

00:00 Introduction and Guest Welcome
01:40 Exploring Carbohydrates and Athletic Performance
03:04 Research Insights on Low Carb Diets
09:10 The Role of Carbohydrates in Endurance Sports
10:10 Debating Muscle Glycogen vs. Blood Glucose
17:23 Adaptation and Supplementation in Low Carb Diets
20:13 Comparing Elite and Amateur Athletes
28:02 Health Implications of Diet in Athletes
32:00 The Hidden Dangers of High Carbohydrate Diets
34:48 The Efficiency of Fat as Fuel
36:14 Understanding the Body's Macronutrient Needs
37:59 The Role of Glucose in Endurance Sports
39:45 Personal Experiences with Zero Carb Diets
42:05 The Future of Zero Carb Research
45:27 The Impact of Diet on Athletic Performance
48:00 The Addiction to Carbohydrates
50:56 The Genetic Factors in Athletic Performance
53:16 The Importance of Resilience in Endurance Sports

https://www.chriscookingnashville.com/recipe-cards?cardid=4743726915108

• 227 g cream cheese (softened)
• 57 g melted butter
• 9.86 ml white vinegar
• 30 g pork panko (or other meat flour)
• 108 g whey protein (or beef isolate)
• 6 g egg white powder
• 59 g butter powder
• 21 g unflavored gelatin
• 2-4 Tbsp allulose (optional; can be subbed for another keto sweetener to taste)
• 1 large whole egg
• 2 egg yolks (or a second whole egg)
• 2 g baking soda
• 2-3 Tbsp cubed butter
• Beef tallow, lard, ghee, bacon grease, or other animal fat for coating baking dish

We saw The Minecraft Movie! Correction: we saw A Minecraft Movie. This movie is a Minecraft movie, because someone had to make it. It stars Jack Black because of course it does. In the film, lights and colors appear on the screen and people in the audience laugh when characters say that their butt hurts. It is truly a magical time at the cinema and we can only hope that this Minecraft Movie is not the only Minecraft Movie.

https://en.wikipedia.org/wiki/A_Minecraft_Movie

Jeremy Jahns "Temu Jumanji" https://youtu.be/hhj16SqR-Yc

Thomas N. Seyfried received his Ph.D. in Genetics and Biochemistry from the University of Illinois, Urbana, in 1976. He did his undergraduate work at the University of New England, where he recently received the distinguished Alumni Achievement Award. He also holds a Master’s degree in Genetics from Illinois State University. Thomas Seyfried served with distinction in the United States Army’s First Cavalry Division during the Vietnam War and received numerous medals and commendations. He was a Postdoctoral Fellow in the Department of Neurology at the Yale University School of Medicine and then served on the faculty as an Assistant Professor in Neurology.

Other awards and honours have come from such diverse organisations as the American Oil Chemists Society, the National Institutes of Health, The American Society for Neurochemistry, the Ketogenic Diet Special Interest Group of the American Epilepsy Society, the Academy of Comprehensive and Complementary Medicine, and the American College of Nutrition.

Dr. Seyfried previously served as Chair, Scientific Advisory Committee for the National Tay-Sachs and Allied Diseases Association and presently serves on several editorial boards, including those for Nutrition & Metabolism, Neurochemical Research, the Journal of Lipid Research, and ASN Neuro, where he is a Senior Editor.

Dr. Seyfried has over 150 peer-reviewed publications and is the author of the book, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (Wiley, 1st ed., 2012).

Publication List https://scholar.google.com/citations?user=ctSRQrsAAAAJ

Here is the paper the talk is largely based from : https://doi.org/10.3389/fcell.2015.00043 - Cancer as a mitochondrial metabolic disease

Here is the proposed press-pulse protocol : https://pubmed.ncbi.nlm.nih.gov/28250801/ - Press-pulse: a novel therapeutic strategy for the metabolic management of cancer

Here is a application of that protocol for glioblastomas : https://pubmed.ncbi.nlm.nih.gov/39639257/ - Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma