I’d be screaming the safe word just by bringing this thing into the room.

It's kinda concerning how people often are taking normal reactions/behaviors and labeling them as autistic or ADHD.

There's a difference between "that's a bit annoying" and "I literally can't think of anything else and I must tear off the tag even if I destroy the shirt and I mean RIGHT now or I'm getting naked"

If you take a single trait, it's almost never autistic or whatever only. But it can be a common one among autistic people.

But there are people who don't care about tags and let them in their clothes.

I read your comment, thought "Am I dealing with one?" and had to reach into my shirt to check if it had one or not. It turns out it does! So... I guess so. I'm irregular in other ways, though, so I might not be a good point of comparison.

The only time I think about them is if I’m dressing in the dark and need to orient a t-shirt

Its annoying to normies.

It causes more or less significant to extreme mental and physical anguish to many autists.

Many autists have basically heightened levels of awareness with one or many of their physical senses, as compared to non autists.

Like, I frequently notice minor visual details in the world around me, that most other people completely miss, tell me I'm lying when I say I saw them, then they go check and are angry that I was right.

Same thing with heightened sensitivity to bright light, as well as extreme repulsion from certain color palettes.

Or, same kind of thing with sounds. Myself, a lot of other autistic people get extremely irritated by low intensity, but perisistent sounds that are either very high or very low frequency ... that most people don't notice untill you tell them to stop and focus, then, they can hear them.

But for autists it is... sometimes literally so annoying it will drive you mad. It causes actual pain from how stressed it makes you.

Its why autists and noise canceling headphones are a thing.

Most 'ASMR' videos?

I'd rather run into brick wall at 20 mph.

ASMR is a thing, but, as a genre of content, its largely a bunch of idiots making the most annoying and aggravating sounds possible, and acting like its soothing.

tl:dr; yeah, its not an autistic only thing, but something like this is fucking kryptonite to autists.

I feel delightfully squirmy, but not in the fun way.

I think "delightfully" is a direct opposite to "not in the fun way"

You got it - clothing tags and random itchy threads.

One can usually tell by the cut of the material. For example, on tshirts, look at where the shoulder seam meets the neck, it will usually be to the back of center.