this post was submitted on 04 Jan 2026
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In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.

Reference: “Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration” by Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau and Nidhi Bhutani, 27 November 2025, Science. DOI: 10.1126/science.adx6649

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[–] NoTagBacks@lemmy.dbzer0.com 108 points 2 months ago (2 children)

Holy shit. Directly treating the cause of cartilage loss with pill-form treatment in human trials right now. The shit we've been doing with medical science recently is fucking wild.

[–] FlashMobOfOne@lemmy.world 29 points 2 months ago

This summer we'll find out the results of the Galleri test trials in the UK. Another game changer potentially.

[–] veroxii@aussie.zone 17 points 2 months ago (2 children)

Would've been useful before I had my foot cut off. 🤷‍♂️

[–] ChairmanMeow@programming.dev 22 points 2 months ago (1 children)

In 20 years you'll get a pill from the pharmacy to grow a new one 😋

[–] Maeve@kbin.earth 7 points 2 months ago (2 children)
[–] 87Six@lemmy.zip 13 points 2 months ago (1 children)

TONIGHT ON DEAL OR NO DEAL:

you can get this new leg but it will cost you a kidney

[–] MrShankles@reddthat.com 6 points 2 months ago (2 children)

I only need one kidney, AND I can have 3 legs. Deal

[–] Hazy@aussie.zone 2 points 2 months ago

I already have 3 😏

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[–] ChairmanMeow@programming.dev 6 points 2 months ago

It might cost you an arm and a leg.

[–] Kirp123@lemmy.world 5 points 2 months ago

That means you don't need your cartilage regrown.

[–] Lemmyoutofhere@lemmy.ca 54 points 2 months ago (4 children)

As a 50+ year old mechanic, this can’t come soon enough.

[–] chonglibloodsport@lemmy.world 20 points 2 months ago (1 children)

Wow yes. So many older and retired workers from the skilled trades could benefit from this.

It would also be a huge boon for recruitment as I imagine young people considering the career may be discouraged by the physical demands of the job and their potential lasting effects.

[–] Damage@feddit.it 5 points 2 months ago

Arthritis is not limited to trade workers, anyone can have it.

And it isn't the only health issue physical work can cause.

[–] roofuskit@lemmy.world 11 points 2 months ago (4 children)

Perfect for making you work the remainder of your life. No more arthritis? Great, now work until death to pay for it.

[–] explodicle@sh.itjust.works 9 points 2 months ago (1 children)

Honestly I'd take that over this arthritis

[–] stringere@sh.itjust.works 2 points 2 months ago

It's in my mouse clicker finger and starting to make video game controllers uncomfortable. Make it stop!

[–] cyberpunk007@lemmy.ca 4 points 2 months ago

Uhg. Sad reality.

[–] Dupelet@piefed.social 3 points 2 months ago (1 children)
[–] roofuskit@lemmy.world 1 points 2 months ago

Or win the lottery.

[–] angrystego@lemmy.world 2 points 2 months ago

I don't think arthritis is the win you think it is.

[–] SaveTheTuaHawk@lemmy.ca 9 points 2 months ago (2 children)

Spoiler alert: you can't afford it.

[–] Dupelet@piefed.social 8 points 2 months ago

Speak for the Americans. The rest of us have no trouble doing so

[–] rumba@lemmy.zip 7 points 2 months ago (4 children)

also cancer :)

Any of the "regrows damage" side of thing scares the fuck out of me. I mean I want it to come and ASAP, but I also don't want to play chicken with C

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[–] hanrahan@piefed.social 8 points 2 months ago

Thank you for doing useful work

[–] Mac@mander.xyz 30 points 2 months ago (1 children)

The rich are going to live well

[–] Dupelet@piefed.social 24 points 2 months ago

So are non Americans

[–] popekingjoe@lemmy.world 28 points 2 months ago
[–] SkunkWorkz@lemmy.world 21 points 2 months ago (2 children)

Bet soon I can buy this from a roided up guy in the locker rooms of my local gym. Middle aged power lifters would love to pop these pills.

[–] musubibreakfast@lemmy.world 3 points 2 months ago

"I just popped a kneecap, it shot clean off and broke a mirror. Pill me babay!"

[–] Lemmar@lemmy.today 1 points 2 months ago (1 children)

Most definitely. I'm almost in that demographic myself and several of the slightly older, nerdy lifters at my gym talk about BPC-157 as something they would consider using.

If this gets proven to work in vivo in humans I'm certain we'll see the same no matter side effects.

[–] blarghly@lemmy.world 1 points 2 months ago

I've also heard the peptide hype. I'm curious, as an aging athletic person - but also I don't want to roll the dice with cancer

[–] Grandwolf319@sh.itjust.works 16 points 2 months ago (2 children)

Between this and growing new teeth, things are looking a lot more cyberpunk than before.

[–] Lawnman23@lemmy.world 9 points 2 months ago (1 children)
[–] Waraugh@lemmy.dbzer0.com 2 points 2 months ago (2 children)

Is that from a game? Kind of looks like Keanu Reeves

[–] Damage@feddit.it 6 points 2 months ago* (last edited 2 months ago)

Cyberpunk 2077, and yeah, it's Keanu Reeves as Johnny Silverhand.

They've got Idris Elba too in the DLC.

[–] Grandwolf319@sh.itjust.works 4 points 2 months ago

Yes and yes.

Cyberpunk 77

[–] Sharkticon@lemmy.zip 5 points 2 months ago

In that only the upper wealthy class will be able to afford it?

[–] Smoogs@lemmy.world 15 points 2 months ago (1 children)

So…there’s a chance I can back into martial arts? Bring it.

[–] stringere@sh.itjust.works 6 points 2 months ago

Martial arts should probably be approached from the front, but you do you, boo.

[–] charade_you_are@sh.itjust.works 7 points 2 months ago (1 children)

What the fuck? All we ever needed was a pill? Is everybody stupid?

[–] wabafee@lemmy.world 7 points 2 months ago (1 children)

Damn mice's at this point they will reach immortality first. Then again thankful for that lol.

[–] pulsewidth@lemmy.world 8 points 2 months ago

They'll deserve it, the shit we've put them through.

I feel there's very little the rest of the world should emulate of modern Russia, but this is one example that I would like to see mimicry of: https://en.wikipedia.org/wiki/Monument_to_the_laboratory_mouse

[–] SocialMediaRefugee@lemmy.world 5 points 2 months ago

I wonder if you'd have to stay off of those joints for months to allow the regrowth to occur properly.

[–] SocialMediaRefugee@lemmy.world 3 points 2 months ago* (last edited 2 months ago) (1 children)

The question is "Does 15-PGDH do something beneficial and would suppressing it have serious side effects?"

I found this:

15-HPGD has an unappreciated role in the maintenance of pregnancy. In mice, 15-HPDG has been shown to have essential roles in prevention of early termination of pregnancy and maternal morbidity. In 15-HPGD knockout mice, early pregnancy termination was detected.

So any 15-HPGD treatment would have to be done with careful consideration of woman of reproductive age.

[–] Taleya@aussie.zone 2 points 2 months ago (1 children)

reproductive urge, you mean.

Plenty of women with the equipment and no intention of using it.

[–] angrystego@lemmy.world 4 points 2 months ago

Well, that's part of what you'd have to consider. The reply didn't state it would be contraindicated in reproductive age, just that it shouldn't be applied without consideration.

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