this post was submitted on 04 Jan 2026
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In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.

Reference: “Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration” by Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau and Nidhi Bhutani, 27 November 2025, Science. DOI: 10.1126/science.adx6649

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[–] NoTagBacks@lemmy.dbzer0.com 107 points 4 days ago (2 children)

Holy shit. Directly treating the cause of cartilage loss with pill-form treatment in human trials right now. The shit we've been doing with medical science recently is fucking wild.

[–] FlashMobOfOne@lemmy.world 28 points 4 days ago

This summer we'll find out the results of the Galleri test trials in the UK. Another game changer potentially.

[–] veroxii@aussie.zone 17 points 4 days ago (2 children)

Would've been useful before I had my foot cut off. 🤷‍♂️

[–] ChairmanMeow@programming.dev 21 points 4 days ago (1 children)

In 20 years you'll get a pill from the pharmacy to grow a new one 😋

[–] Maeve@kbin.earth 7 points 4 days ago (2 children)
[–] 87Six@lemmy.zip 13 points 4 days ago (1 children)

TONIGHT ON DEAL OR NO DEAL:

you can get this new leg but it will cost you a kidney

[–] MrShankles@reddthat.com 6 points 4 days ago (2 children)

I only need one kidney, AND I can have 3 legs. Deal

[–] Hazy@aussie.zone 2 points 4 days ago

I already have 3 😏

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[–] ChairmanMeow@programming.dev 6 points 4 days ago

It might cost you an arm and a leg.

[–] Kirp123@lemmy.world 5 points 4 days ago

That means you don't need your cartilage regrown.

[–] Lemmyoutofhere@lemmy.ca 53 points 4 days ago (4 children)

As a 50+ year old mechanic, this can’t come soon enough.

[–] chonglibloodsport@lemmy.world 20 points 4 days ago (1 children)

Wow yes. So many older and retired workers from the skilled trades could benefit from this.

It would also be a huge boon for recruitment as I imagine young people considering the career may be discouraged by the physical demands of the job and their potential lasting effects.

[–] Damage@feddit.it 5 points 4 days ago

Arthritis is not limited to trade workers, anyone can have it.

And it isn't the only health issue physical work can cause.

[–] hanrahan@piefed.social 8 points 4 days ago

Thank you for doing useful work

[–] roofuskit@lemmy.world 11 points 4 days ago (4 children)

Perfect for making you work the remainder of your life. No more arthritis? Great, now work until death to pay for it.

[–] explodicle@sh.itjust.works 9 points 4 days ago (1 children)

Honestly I'd take that over this arthritis

[–] stringere@sh.itjust.works 2 points 4 days ago

It's in my mouse clicker finger and starting to make video game controllers uncomfortable. Make it stop!

[–] Dupelet@piefed.social 3 points 4 days ago (1 children)
[–] roofuskit@lemmy.world 1 points 4 days ago

Or win the lottery.

[–] cyberpunk007@lemmy.ca 4 points 4 days ago

Uhg. Sad reality.

[–] angrystego@lemmy.world 2 points 3 days ago

I don't think arthritis is the win you think it is.

[–] SaveTheTuaHawk@lemmy.ca 9 points 4 days ago (2 children)

Spoiler alert: you can't afford it.

[–] Dupelet@piefed.social 8 points 4 days ago

Speak for the Americans. The rest of us have no trouble doing so

[–] rumba@lemmy.zip 7 points 4 days ago (4 children)

also cancer :)

Any of the "regrows damage" side of thing scares the fuck out of me. I mean I want it to come and ASAP, but I also don't want to play chicken with C

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[–] Mac@mander.xyz 30 points 4 days ago (1 children)

The rich are going to live well

[–] Dupelet@piefed.social 24 points 4 days ago

So are non Americans

[–] popekingjoe@lemmy.world 28 points 4 days ago
[–] SkunkWorkz@lemmy.world 21 points 4 days ago (2 children)

Bet soon I can buy this from a roided up guy in the locker rooms of my local gym. Middle aged power lifters would love to pop these pills.

[–] musubibreakfast@lemmy.world 3 points 4 days ago

"I just popped a kneecap, it shot clean off and broke a mirror. Pill me babay!"

[–] Lemmar@lemmy.today 1 points 3 days ago (1 children)

Most definitely. I'm almost in that demographic myself and several of the slightly older, nerdy lifters at my gym talk about BPC-157 as something they would consider using.

If this gets proven to work in vivo in humans I'm certain we'll see the same no matter side effects.

[–] blarghly@lemmy.world 1 points 1 day ago

I've also heard the peptide hype. I'm curious, as an aging athletic person - but also I don't want to roll the dice with cancer

[–] Smoogs@lemmy.world 15 points 4 days ago (1 children)

So…there’s a chance I can back into martial arts? Bring it.

[–] stringere@sh.itjust.works 5 points 4 days ago

Martial arts should probably be approached from the front, but you do you, boo.

[–] Grandwolf319@sh.itjust.works 16 points 4 days ago (2 children)

Between this and growing new teeth, things are looking a lot more cyberpunk than before.

[–] Lawnman23@lemmy.world 9 points 4 days ago (1 children)
[–] Waraugh@lemmy.dbzer0.com 2 points 4 days ago (2 children)

Is that from a game? Kind of looks like Keanu Reeves

[–] Damage@feddit.it 6 points 4 days ago* (last edited 4 days ago)

Cyberpunk 2077, and yeah, it's Keanu Reeves as Johnny Silverhand.

They've got Idris Elba too in the DLC.

[–] Grandwolf319@sh.itjust.works 4 points 4 days ago

Yes and yes.

Cyberpunk 77

[–] Sharkticon@lemmy.zip 5 points 4 days ago

In that only the upper wealthy class will be able to afford it?

I wonder if you'd have to stay off of those joints for months to allow the regrowth to occur properly.

[–] wabafee@lemmy.world 7 points 4 days ago (1 children)

Damn mice's at this point they will reach immortality first. Then again thankful for that lol.

[–] pulsewidth@lemmy.world 8 points 4 days ago

They'll deserve it, the shit we've put them through.

I feel there's very little the rest of the world should emulate of modern Russia, but this is one example that I would like to see mimicry of: https://en.wikipedia.org/wiki/Monument_to_the_laboratory_mouse

[–] charade_you_are@sh.itjust.works 7 points 4 days ago (1 children)

What the fuck? All we ever needed was a pill? Is everybody stupid?

[–] SocialMediaRefugee@lemmy.world 3 points 4 days ago* (last edited 4 days ago) (1 children)

The question is "Does 15-PGDH do something beneficial and would suppressing it have serious side effects?"

I found this:

15-HPGD has an unappreciated role in the maintenance of pregnancy. In mice, 15-HPDG has been shown to have essential roles in prevention of early termination of pregnancy and maternal morbidity. In 15-HPGD knockout mice, early pregnancy termination was detected.

So any 15-HPGD treatment would have to be done with careful consideration of woman of reproductive age.

[–] Taleya@aussie.zone 2 points 4 days ago (1 children)

reproductive urge, you mean.

Plenty of women with the equipment and no intention of using it.

[–] angrystego@lemmy.world 4 points 3 days ago

Well, that's part of what you'd have to consider. The reply didn't state it would be contraindicated in reproductive age, just that it shouldn't be applied without consideration.

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