this post was submitted on 22 Dec 2025
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When the researchers conducted spatial learning and memory tests using the Barnes maze, the aspartame mice at four months consistently moved more slowly and covered less distance during training than animals in the control group. They also took nearly twice as long on average to locate the target escape hole, showing impaired memory recall (however, this was inconsistent and not seen as statistically meaningful). By eight months, performance gaps widened even further, with two out of six aspartame-treated mice failing to complete the task at all.

It makes you dumb, unfit and fat (around the organs).

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[–] TheTechnician27@lemmy.world 71 points 8 months ago* (last edited 8 months ago) (2 children)

Here's the actual open-access study instead of clickbait tabloid trash. One of the study's conclusions is pretty chilling:

Until the neurological sequelae of aspartame are better understood, children and adolescents should probably avoid aspartame as far as possible,

[–] ulterno@programming.dev 17 points 8 months ago* (last edited 8 months ago) (5 children)

I always tend to avoid stuff with the "Diet" or "sugar free" labels, just for this reason.
And it didn't require a study to convince me that random stuff that is not a part of nutrition, is better off being out of a regular diet.
But it definitely takes a study to validate my concerns.

[–] SaveTheTuaHawk@lemmy.ca 6 points 8 months ago (1 children)

The big problem with diet sodas is that the pancreas is activated by the taste of sweet, not just blood sugar levels. People drink gallons of this garbage a year and diabetes rates only go up.

[–] ReluctantMuskrat@lemmy.world 9 points 8 months ago (1 children)

My understanding is this is just with sucralose. You can easily validate this yourself with a continuous glucose monitor. Diet sodas have their problems and the one in this article is particularly concerning but they don't typically trigger insulin responses.

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[–] DaTingGoBrrr@lemmy.world 4 points 8 months ago

Exactly my reasoning as well. My body knows what sugar is and how to handle it.

[–] Lumidaub@feddit.org 3 points 8 months ago (2 children)

Fiber also has no nutritional value.

[–] Hamartiogonic@sopuli.xyz 8 points 8 months ago (4 children)

Fun little technicality. It won’t provide energy, fat or protein, but it does serve an important function nonetheless. Does that count as “value”? Depends on who you ask.

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[–] ulterno@programming.dev 3 points 8 months ago* (last edited 8 months ago) (4 children)

Still a part of nutrition though, no?

I'll also take this opportunity to point out that taking just fibre is not particularly useful either.
It only really makes sense when in conjunction with other substances in forms that come with traditional foods.

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[–] rowinxavier@lemmy.world 39 points 8 months ago (2 children)

Before you take this to mean anything about why you should do, you are not a mouse. This is a study in mice and the differences between what impacts it will have in mice and humans may be very large. Mice are not good human analogues, but they are very cheap and good model organisms.

The findings they report include weight loss and cardiac/neurological impacts. This appears to compound over time with worse impacts as the study continued. This would make sense if the impact of aspartame was a slow chronic toxin or inhibited some normal pathway. If it is the former then avoiding aspartame for mice is important at all times. If it is the latter then having a break every so often should ameliorate the damage, though how much and what time ratio is not tested here.

That said, this is in mice. In my experience human brains a fairly different from mouse brains and the metabolic context is also quite different. I doubt the applicability of this to humans will be replicated well any time soon. If they do find an issue it is likely to be different to what happened to the mice, and though it is possible this will carry over to humans it is unlikely.

[–] Agent641@lemmy.world 11 points 8 months ago (1 children)

Also to point out, this doesn't implicate any other artificial sweetemers. If you're in Australia, the sweetenersight be listed by code rather than name:

[–] rowinxavier@lemmy.world 3 points 8 months ago (1 children)

Also you will usually find 950 (aspartame) along with 951 (acesulfame K) because the two have slightly different profiles and work very well together. If we do a study on humans I would want it to include the common and also some uncommon combinations. A lot of people are switching over to erythritol and stevia but I don't know how safe they are. We make erythritol internally but the dose may be quite different, and coming in through the gut could be quite different to internal production, not to mention with the stevia as actually prepared not lab purified.

[–] ProdigalFrog@slrpnk.net 3 points 8 months ago* (last edited 8 months ago)

Erythritol in particular actually had a study recently that was also concerning

[–] olafurp@lemmy.world 3 points 8 months ago

I agree, they're not good humans and I'd love to get some more eyes on aspartame in light of this study. I did the math (and posted a comment on this post) and found out that the dose is equivalent to a 2L coke zero bottle so the dosage is applicable to how much humans get.

It's a classic more study needed and until we get a proper study without conflict of interest assessing human cognitive performance with a memory test after 8 months of drinking a 2L bottle of coke zero 3 times per week I'd recommend reducing the amount of aspartame drinks to at 0.5L or less 3 times a week.

It's not conclusive that it's going to negatively affect humans and sugary alternatives are very likely still less healthy both cognitively and physically than the zero drinks.

[–] 9point6@lemmy.world 22 points 8 months ago (1 children)

We have an unfortunate monkey paw thing regarding this in the UK now then

We introduced a sugar tax a few years ago to try and reduce the amount of sugar in food, it has been quite successful in that regard. However in many, many places, aspartame is the substitute ingredient.

Most cases you can avoid given it's generally unhealthier food, but I'm not a monk, so I'm going to consume junk on occasion.

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[–] olafurp@lemmy.world 13 points 8 months ago (1 children)

Dosage matters so I crunched the numbers to get the Coke Zero equivalent.

  • Coke Zero has 85mg/355ml
  • Mice were dosed with 7mg/kg, 3 times per week
  • We assume humans are 75kg.

Calculation

  • Human dose is 7mg/kg * 75kg = 525mg
  • 525mg / (85mg / 355ml) = 2193ml

So it's roughly same as drinking a 2L (half gallon) bottle. I expected it to be a lot bigger, not just something a regular soda lover would reach in 2 days.

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[–] Hamartiogonic@sopuli.xyz 12 points 8 months ago (16 children)

Hmm… sounds like avoiding all sorts of sweet things might be worth considering.

[–] Angelevo@feddit.nl 15 points 8 months ago (7 children)

Just use natural sugars in moderation and you will be fine.

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[–] SaveTheTuaHawk@lemmy.ca 3 points 8 months ago (2 children)

The pancreas is activated to produce insulin by first the sense of taste and sweetness, then by blood sugar levels.

This is why since the large scale adoption of synthetic sweetners, diabetes rates of skyrocketed. People don't even drink water now in US.

[–] angband@lemmy.world 4 points 8 months ago

that's debatable based on the literature: https://pubmed.ncbi.nlm.nih.gov/28148491/

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[–] angband@lemmy.world 9 points 8 months ago
[–] Anti_Iridium@lemmy.world 6 points 8 months ago

Aspartame? The most studied of the artificial sweeteners? The one that breaks down completely?

[–] radiouser@crazypeople.online 6 points 8 months ago

It makes you dumb, unfit and fat

Well, I've been that way my entire life.

[–] Jollyllama@lemmy.world 5 points 8 months ago (1 children)

Phew, thank God I'm not a mouse. I'll keep drinking my diet sodas.

[–] SaveTheTuaHawk@lemmy.ca 7 points 8 months ago (15 children)
[–] Strider@lemmy.world 8 points 8 months ago

Water... Like from the toilet?

(obligatory /s)

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[–] liuther9@lemmy.world 4 points 8 months ago

Useless study. Why would we care about mice drinking coke zero?

[–] FosterMolasses@leminal.space 4 points 8 months ago
[–] DarrinBrunner@lemmy.world 3 points 8 months ago

My (long-since-ex) wife called it over twenty years ago, "That crap is worse than sugar." Our kids didn't get artificial sweeteners. (Nor did they get too much real sugar, we didn't have fat kids.)

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