As I understand the readme, for blocking usual apps root privileges are required:
Please note: For normal applications, the Shell permission in Shizuku mode is not sufficient to change the switch status of components. In other words, unmodified APKs do not support non-root modification. If you want to use Shizuku to modify the component status of normal applications, please start Shizuku with Root privileges.
It should work without root privileges for apps in 'testing mode'. Yet, they only provide a guide to flag apps as 'testing' in Chinese language.