this post was submitted on 21 Jun 2026
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"This is the first study to show that [the compound] Cu(ATSM) can increase the abundance of P-gp clearance pumps in an Alzheimer's model, by 24.1 percent, effectively linking the repair of the blood-brain barrier to a reduction in toxic proteins and improved cognitive function," Dr. Pyun said.

"By improving the pumps, the brain can finally clear out the trapped waste. Over 56 days, the treatment reduced toxic amyloid-beta by 42 percent and improved spatial learning by nearly 44 percent."

"Cu(ATSM) is a copper compound with anti-inflammatory and neuroprotective properties that has already progressed to clinical testing for conditions like Parkinson's and ALS," Professor Nicolazzo said.

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[–] pound_heap@lemmy.dbzer0.com 1 points 5 minutes ago

Oh, I bet copper from Flock cameras has this effect too!

[–] Lumisal@lemmy.world 18 points 9 hours ago (1 children)

They've tried it with Gold too (Au{TISM}) but it had some interesting side effects, so wonder what side effects Cu(ATSM) will have.

[–] AA5B@lemmy.world 6 points 5 hours ago* (last edited 5 hours ago)

Maybe we’ll finally be able to live out our dreams of acting as captain James T Kirk, wandering the galaxy to have sex with green-skinned women

Maybe we’ll party with that blue skinned guy taking colloidal silver and a bunch of furries, to declare ourselves the Federation

[–] Gonzako@lemmy.world 14 points 10 hours ago (1 children)

Hope theyll be able to make review on wether it's good or bad quality copper

[–] UnderpantsWeevil@lemmy.world 2 points 1 hour ago

Going to be weird when we've got people salvaging their dead grandparents' foreheads for recycleable metal.

[–] HeyThisIsntTheYMCA@lemmy.world 20 points 11 hours ago* (last edited 9 hours ago) (3 children)

Didn't the amyloid-beta model get disproven? I am not following AD research that closely (I follow DBS research in neuro) but I remember reading a specific model (one that most of the research was tied up in) was disproven and it's why none of the mouse models were working on humans.

edit: what timing. I just popped back on here and saw @ParadoxSeahorse@lemmy.world posted this article. I can't vouch for its contents as i'm not an AD researcher, but i think it's what i'm remembering

[–] ParadoxSeahorse@lemmy.world 8 points 7 hours ago

Thanks. From the article:

One of its biggest mysteries is also its most distinctive feature: the plaques and other protein deposits that German pathologist Alois Alzheimer linked to the disease in 1906. In 1984, Aβ was identified as the main component of the plaques. And in 1991, researchers traced family-linked Alzheimer’s to mutations in the gene for a precursor protein from which amyloid derives.

I haven’t checked all the sources, but the Aβ model predates the fraudulent papers, which were focused on the Aβ*56 “toxic oligomer” species. However, the model wasn’t looking too hot before hand, and it really resuscitated it. Now yeah, it may have been a zombie

[–] elucubra@sopuli.xyz 4 points 9 hours ago (1 children)

I seem to remeber that the Amyloid plaques are now considered caused by whatever causes Alzheimers, but are not the cause.

[–] HeyThisIsntTheYMCA@lemmy.world 2 points 9 hours ago

i dunno. it just smells to me like they're waiting for Lesne to die so they can start doing real science again.

[–] Feathercrown@lemmy.world 2 points 10 hours ago

I heard this as well

[–] Abyssian@lemmy.world 11 points 11 hours ago (1 children)

Wait till they find out about the copper magnet bracelets that cure everything.

[–] AA5B@lemmy.world 2 points 5 hours ago (1 children)

I’m waiting for all the online videos about how it’s actually caused by a parasite, and you can cure yourself with “this one simple trick”

[–] Abyssian@lemmy.world 1 points 1 hour ago

I bet doctors hate that one simple trick. And also recommend it, but won't tell you about it in person.

[–] qualia@lemmy.world 93 points 17 hours ago (5 children)

CNS disease drugs (Alzheimer's, stroke, ALS) translate from mice to humans under 10% of the time. Mouse models like the referenced primary source are poor proxies as they're engineered for single, clean pathologies (e.g. one mutation), while human neurodegeneration is messier, multifactorial, and not fully replicated even when surface features like amyloid plaques appear.

[–] spaghettiwestern@sh.itjust.works 32 points 17 hours ago (2 children)

Since it's already in clinical trials for ALS and Parkinson's, hopefully testing for Alzheimer's can be done much more quickly than otherwise would be possible.

[–] HeyThisIsntTheYMCA@lemmy.world 19 points 11 hours ago* (last edited 11 hours ago)

Clinical trials for als are a crapshoot. They'll approve anything for a trial because what can it hurt

Source: dad was in the radicava trial. Can't prove it, but he went fast. Probably faster than he would have without. They excluded him from the dataset because he was inconvenient.

[–] sudoshakes@reddthat.com 3 points 14 hours ago

It can pass phase 2 easier but not phase 3 trails.

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[–] bluGill@fedia.io 58 points 18 hours ago (2 children)

In mice.. Time will tell, but Alzheimer dugs have a poor history in human trials. Some of even suggested that the model this is working on is wrong and thus it cannot work.

[–] becausechemistry@piefed.social 14 points 16 hours ago

Yeah. The trouble is that pretty much only humans get Alzheimer’s. In order to make a mouse model, we have to induce a disease state that looks like Alzheimer’s, at least to our best understanding. It’s not unreasonable that our mouse model is just not really representative of the actual disease in humans.

[–] Tollana1234567@lemmy.today 1 points 9 hours ago

i wonder if this works for Amyloidosis , which forms amyloid plaques

[–] DarkCloud@lemmy.world 13 points 18 hours ago* (last edited 18 hours ago) (5 children)

Cool, so they'll get bought up by an Alzheimer's medicine company that produces a medicine that doesn't work, and we'll never hear of this breakthrough again.

Capitalism is great at killing off medicines that work, there's less profit in medicines that work.

[–] surewhynotlem@lemmy.world 36 points 17 hours ago (1 children)

produces a medicine that doesn't work

There's no reason to be needlessly jaded. Those companies would absolutely produce this if it worked, because you'd have to take it forever.

[–] AwesomeLowlander@sh.itjust.works 9 points 16 hours ago (1 children)

The Internet is full of Dunning Kruger idiots who don't understand profit maximisation but believe they do.

[–] Jake_Farm@sopuli.xyz 4 points 15 hours ago (2 children)

Given the number of bubbles that collapse the economy, neither does Wallstreet

[–] surewhynotlem@lemmy.world 1 points 2 hours ago

The bubble is the point. They maximize their profits and then leave the rest of the idiots holding the bag.

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[–] JasonDJ@lemmy.zip 8 points 14 hours ago

Wdym? If a drug like this were successful, everybody with any markers for Alzheimer's would want to be in on it. They'd make bank for several years, until the patent expires, and then they'd have other methods of extending the patent and prolonging market exclusivity.

Sorry but this is a shit talking point. What drug companies fear is the eradication of an ailment, and particularly by non-pharmaceutical means (i.e. gene therapy).

Even something that's 100% effective in preventing Alzheimer's, would still see a hell of a market.

And if such a drug is possible, then there's the game theory question. Any pharma exec knows that if their company can make a breakthrough medicine...so too could another company. Is it worth it for them to sit on it, only for another company to make the same discovery a year or two later and bring it to market?

[–] protist@retrofed.com 7 points 15 hours ago

This doesn't make sense though, if they have a drug that works, they'll make fucking bank. Pharmaceutical companies would kill for a blockbuster drug like that

[–] Jake_Farm@sopuli.xyz 4 points 15 hours ago

Conspiracy theorists alert! Bet you are antivax too.

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[–] hot_mocha_decaf@lemmy.cafe 5 points 18 hours ago (1 children)

I have this habit of sucking on pennies, helps clear my head. Maybe there's something to this.

[–] tempest@lemmy.ca 9 points 16 hours ago* (last edited 16 hours ago) (2 children)

Very little copper in modern pennies, you should probably just supplement zinc. Helps with colds as well.

[–] qualia@lemmy.world 4 points 10 hours ago

A 2024 massive Cochrane review didn't find enough evidence to recommend zinc for colds.

[–] MyTurtleSwimsUpsideDown@fedia.io 11 points 15 hours ago

Proportionally little copper in modern pennies. But the outside is a thin veneer of copper plating. Unless they are nomming on an individual coin long enough the for their saliva to eat through the copper layer like the chocolate on a peanut m&m, then their exposure is no different than a wholey copper coin.

[–] WhyIHateTheInternet@lemmy.world 4 points 18 hours ago* (last edited 17 hours ago) (10 children)

Sounds like those hookey copper bands and junk they used to sell weren't hokum after all lol

Edit - /s

[–] pelespirit@sh.itjust.works 4 points 18 hours ago (7 children)

I wonder how they feel about magnets, lol.

[–] protist@retrofed.com 3 points 15 hours ago (1 children)

Well, TMS is a real thing, and increasingly evidence-based

[–] HeyThisIsntTheYMCA@lemmy.world 2 points 11 hours ago

The Magnet Syndrome?

[–] WhyIHateTheInternet@lemmy.world 4 points 17 hours ago

You can't explain that

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