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Copper drug clears toxic Alzheimer’s proteins and restores memory (www.sciencedaily.com)

submitted 22 hours ago* (last edited 22 hours ago) by spaghettiwestern@sh.itjust.works to c/upliftingnews@lemmy.world

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"This is the first study to show that [the compound] Cu(ATSM) can increase the abundance of P-gp clearance pumps in an Alzheimer's model, by 24.1 percent, effectively linking the repair of the blood-brain barrier to a reduction in toxic proteins and improved cognitive function," Dr. Pyun said.

"By improving the pumps, the brain can finally clear out the trapped waste. Over 56 days, the treatment reduced toxic amyloid-beta by 42 percent and improved spatial learning by nearly 44 percent."

"Cu(ATSM) is a copper compound with anti-inflammatory and neuroprotective properties that has already progressed to clinical testing for conditions like Parkinson's and ALS," Professor Nicolazzo said.

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[–] HeyThisIsntTheYMCA@lemmy.world 20 points 14 hours ago* (last edited 12 hours ago) (3 children)

Didn't the amyloid-beta model get disproven? I am not following AD research that closely (I follow DBS research in neuro) but I remember reading a specific model (one that most of the research was tied up in) was disproven and it's why none of the mouse models were working on humans.

edit: what timing. I just popped back on here and saw @ParadoxSeahorse@lemmy.world posted this article. I can't vouch for its contents as i'm not an AD researcher, but i think it's what i'm remembering

[–] ParadoxSeahorse@lemmy.world 9 points 10 hours ago

Thanks. From the article:

One of its biggest mysteries is also its most distinctive feature: the plaques and other protein deposits that German pathologist Alois Alzheimer linked to the disease in 1906. In 1984, Aβ was identified as the main component of the plaques. And in 1991, researchers traced family-linked Alzheimer’s to mutations in the gene for a precursor protein from which amyloid derives.

I haven’t checked all the sources, but the Aβ model predates the fraudulent papers, which were focused on the Aβ*56 “toxic oligomer” species. However, the model wasn’t looking too hot before hand, and it really resuscitated it. Now yeah, it may have been a zombie

[–] elucubra@sopuli.xyz 4 points 12 hours ago (1 children)

I seem to remeber that the Amyloid plaques are now considered caused by whatever causes Alzheimers, but are not the cause.

[–] HeyThisIsntTheYMCA@lemmy.world 2 points 11 hours ago

i dunno. it just smells to me like they're waiting for Lesne to die so they can start doing real science again.

[–] Feathercrown@lemmy.world 2 points 12 hours ago

I heard this as well