If we're being honest with ourselves: not really. Toilet paper is a fuel, computers are not. Warehouse Luigi was a symptom not the solution. You would have to be a lot more clever than that to take out something like a data center.

Any prospective data center Luigi would have to realize that unlike that warehouse, data centers have some really heavy duty utility connections. The water for their cooling systems would probably be able to put out any fire they attempted to start, but it can cause enormous damage to computers and electronics if it somehow ended up somewhere it wasn't supposed to be, so they usually put it outside the building, like on the roof where the cooling equipment is. Fiber optic trunk lines are notoriously difficult to splice and repair when damaged by a stray excavator, that's why they have more than one. Copper for power lines is extremely valuable and commonly stolen, and they know this, so if those power lines were ever cut and stolen, they would use natural gas lines to power their turbine backup generators, so they have a continuous source of flammable, explosive gas on-site that you can't interrupt. So as I've hopefully effectively described here, they've already thought of everything and there's no point trying to take out a data center the way Warehouse Luigi did.

I imagine they would have better air flow

Fly some drones over it and drop some molys on it.