“Whatever fits on a flashcard” is my golden rule.
If the players are visiting a new city/town, the city/town gets a POI list and a key NPC list on the card. Each major NPC gets a flashcard. Each special item the players get goes on a flashcard that I can hand them when they receive or find the item.
Granted, I usually have a plaintext markdown doc that sketches out how I’m planning to weave the pieces together for each session, but each piece of the story in that doc? Written on a flashcard.