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I mean this is just dumb. Like I’m sorry but this would happen with basically every medicine or drug. They aren’t made to be taken at higher doses than advised.
(Imagine you took 8 liters of beer per day for 3 days, you’d be half dead too.)
Moderation people…
You haven't seen the ridiculous quantities that some alcoholics will consume
Paramedic here, once brought someone in who ended up having a blood alcohol of .64. Dude got to sober up in the ICU.
Tolerance is a different beast. But 8 liters of beer is ridiculous.
Humans drink 2-3 liters a day. Of water.
Moderation people…
We don't do that in Eastern Europe™
It's why in the UK shops won't sell more than 2 packets at a time. It's statistically reduced the amount of people killing themselves with them (intentionally or by mistake).
How much is a "packet"? edit: never mind, I found several conflicting answers in the other comments, no need to add even more and add to the confusion.
Too much
He's not the first one to 'kill his liver' with paracetamol/ acetominophen (tylenol). First case I recall, the person was taking tylenol nightly with a glass of wine. Here's some links on the current understanding of Liver injury and paracetamol:
Apparently it's not always overdosing: Paracetamol-induced hepatotoxicity at recommended dosage (https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2796.2003.01097.x)
Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update (https://pmc.ncbi.nlm.nih.gov/articles/PMC4913076/) "...in the United States, in particular, it accounts for more than 50% of overdose-related acute liver failure and approximately 20% of the liver transplant cases."
Risk Factors for Hepatotoxicity Due to Paracetamol Overdose in Adults (https://www.mdpi.com/1648-9144/57/8/752) "In the univariable analysis, significant hepatotoxicity risk factors were male gender, alcohol abuse, an ingested paracetamol dose, and a timespan from ingestion to hospital admission. The later one was the only significant risk factor in the multivariable model (adjusted odds ratio 1.08; 95% CI: 1.03–1.12)."
Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease (https://pubmed.ncbi.nlm.nih.gov/37436926/) "Where data were available, we estimate that paracetamol is involved in 6% of poisonings, 56% of severe acute liver injury and acute liver failure, and 7% of drug-induced liver injury."
Understanding paracetamol-induced liver failure (https://link.springer.com/article/10.1007/s00134-014-3293-9)
Let's say the maximum recommended dose is the "dangerous dose." That's 4 grams. 20x4=80 grams of paracetamol/acetaminophen. That's like 160 goddamn pills
The maximum recommended dose is generally much below the LD50 of a drug.
It also tends to be the maximum recommended dose for short term dosage for painkillers.
His issue was taking this for a long period.
Everyone's discussing ODing on OTC pain meds but the bigger part of this story is why he's in so much pain for so long without being able to see a Dr and receive treatment for chronic pain.
I mean... Yeah. There are instructions on the packet. They aren't supposed to be eaten like candy.
They should have just printed him a Darwin award on a piece of single ply toilet paper and sent him on his way.
Isn't this why they specifically put acetaminophen in opioid+nsaid prescription painkillers, instead of ibuprofen or aspirin or naproxen? Just to discourage abuse because if you take too much it'll destroy your liver. Has always seemed a bit fucked up to me.
Hah, im a psycho so i usually rawdog everything you would have to take painkillers for. Also i prefer not to get addicted to painkillers but thankfully that is pretty rare here in europe especially compared to the us.
I’m mostly the same way.
Opioids make me physically ill and do not interact with my system well at all so I avoid them as much as I possibly can. I take it as a blessing that it puts me away from addiction risk, but it sucks when the rare Tylenol (acetaminophen/paracetamol) doesn’t cut it as my asthma makes NSAIDs a no-go.
Still, I’ll take swearing-pain over dizziness and breathing issues. Been tempted to take a knife to the problem areas myself though.
In the US, the FDA tried to limit how strong the individual capsules can be (325mg), but you can still buy it in 500mg strength. There are mandatory warnings on the label, but you can buy it in 500-tablet (at 325 or 500) bottles over the counter. It took almost 60 years before the FDA did anything, so a lot of people grew up thinking it was harmless.