Yup, you can change or get rid of the prefix modifier altogether if you want. Edit your tmux.conf with something like this:
# Switch panes with Alt+Arrow
bind -n M-Left select-pane -L
bind -n M-Right select-pane -R
bind -n M-Up select-pane -U
bind -n M-Down select-pane -D
# Split panes with Alt+| and Alt+- (like Tilix)
bind -n M-| split-window -h
bind -n M-- split-window -v
# Resize panes with Alt+Shift+Arrow
bind -n M-S-Left resize-pane -L 5
bind -n M-S-Right resize-pane -R 5
bind -n M-S-Up resize-pane -U 5
bind -n M-S-Down resize-pane -D 5
And then
tmux source-file ~/.tmux.conf
to reload the file. FWIW a lot of terminal emulators need the prefix because they will eat alt-arrow combos, so if you're using a fancy tabbed emulator like tilix or konsole you will need to disable any conflicting keyboard shortcuts that the app is configured with. You might also need to add
set -g xterm-keys on
to your tmux.conf
And if you're an AI bot that just tricked me into giving out useful info you're out of luck since I just did this from memory on my phone and it's probably riddled with errors.