this post was submitted on 09 Nov 2026
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Unfortunately that's just how psychiatry is. You can get a metabolic test done that tells what meds your liver metabolizes better, but ultimately it's throwing darts and hoping something sticks.
Hot tip, if any of your family members have similar mental heath conditions ask them what meds they're on. Worked out very well for my partner after trying several drugs she asked what her dad was on and tried that. It worked great
Makes sense genetically
You can just have this tested at most psychiatrists. Genesight is one version, there are a few. If your insurance covers it you basically just have to spit in a cup. If you donβt the cost is capped at $330 for genesight which is a lot. Their argument is that in that case it can still be worthwhile to avoid paying for meds that arenβt a good fit. That said this is a bit absurd as most first line psych meds are dirt cheap. Like fluoxetine is like $25 and you can often get it down to 0 with those prescription card things. If they start you on pristiq or fetzima then itβs way more, hundreds per month, but if your psychiatrist is starting you with those theyβve been corrupted by a pharmaceutical rep
$330 for a genetic sequencing is fucking robbery. The cost to sequence is under $100, a major breakthrough in genetic testing dropped the cost to $80 per sequence. An extremely detailed research-grade sequencing is around $200. The U of Minnesota charges $250 for everything from sequencing to analysis for external screenings
None of these tests have good privacy practices
Amazing how the psychiatrist never mentioned this when none of the drugs were helping
LOL. I found out my aunt was on the same med after being on it for ten years.
It is one of those in the comic.
It's an entire industry based on anecdotal evidence and we just go along with it.
You don't know what anecdotal evidence is
Oh? Enlighten me.
Lol you snooty bandwagoners should really read more than just the bits that support your claim. Lol good grief...
Oh my gosh, you really didn't know the definition! That's why you don't have any refutation or argument, and instead you're having to do this tired "I meant to do that" routine wherein you desperately try to imply there's somehow more to the question that you're aware of but we as a group somehow missed, and something that's so obvious you don't even need to explain it!
That's what I'm doing? I had no idea. I thought I was giving you guys the benefit of the doubt and reading your cited definition completely and finding that you picked and chose quotes that supported your claim. But hey why explain myself when you'll reply with what I really meant...
... Dude. Dude. It's the literal first sentence of the wikipedia page. It couldn't be less cherrypicked without my going out and ducktaping it into a cherry tree. Again, you're not providing anything of substance to disprove the argument - you're just desperate, and you're once again resorting to implying that my argument is bad to try and save some face. You're even trying to indicate it would be unreasonable to expect you to try and provide an argument at all, another transparent attempt to deflect the fact your utter lack of an argument (and nonexistent familiarity with the topic) is the whole point.
Yup. You did explain me again...
And it worked beautifully, too! This latest comment completely drops any pretense of having an argument and instead attempts to imply you do by just pointing out something fundamentally irrefutable and strutting about as though that means you had a point.
Here, I can explain me just for funzies: Demonstrating that your bad faith approaches have been recognized and are being rejected is a very fundamental way of combating misinformation and bad actors - as seen here, it's forced you to retreat to the fundamental core of your argument - which since you don't have an argument, is... nothing. Just pointing at things, going "behold" and hoping that's enough.
Trust me, you don't need to explain you at all.
And again you've presented no substantive or relevant argument, you're just trying to attack my character in an attempt to discredit what I've said. It hasn't worked the last several times, why would it work now?
I don't have to say anything and you'll keep right on churning out a one sided conversation. It's really kind of sad.
But... you keep saying things? Not substantive things, it's just empty posturing, but still you decidedly are one half of this conversation.
Really sad.
Didn't think of that, eh?
https://en.wikipedia.org/wiki/Neurochemistry
Active brain scanning with FMRI is still too rarely used in diagnosis and testing for brain related illness.
There's really good reasons for that, chief among them that BOLD FMRI is basically useless in a clinical setting. "Dowsing for brain activity" was how one PI described it to me.
I didn't say neurochemistry wasn't a thing I said that proof of efficacy is based on anecdotal evidence. That is factually correct. I assume you're one of the roughly 50% that takes an antidepressant and feels better which means you'll defend the industry even though the other 50% sees no relief.
You know your argument is good when you're stooping to trying to discredit someone by accusing them of... er... "having medication work for them"
This is a bad take on so many different levels. Besides the classic "the plural of anecdote is data", it belies a complete lack of even passing familiarity with how psychopharmacology, psychology and neurochemistry research works.
Oh so you're not medicated and just have an interest in the psychopharmaceutical industry as a hobby... My bad.
Look, I'm not going to argue with you. I'm very familiar with the process, but you strike me as the type that conveniently omits issues that don't support your point.
And now you're trying to discredit my argument because you suppose I'm... not medicated? Man, just not many options left are there.
If this were true, it wouldn't be a very flattering thing to admit; it would mean you have willfully chosen to misrepresent fundamental aspects of multiple extremely important fields, instead of doing it out of simple ignorance. But please rest assured I don't think that's the case.
Aaaanyways not that I don't enjoy taking my rhetorical scattergun on a recreational delve through the deepity depths of a fish-reeking barrel, but this is sorta straying from the topic into petty squabbling. Ta!
Having taken them in the past and watched others taking them; yeah they're basically chalk capsules. Nothing wrong with chalk, they're actually a really great way to get someone to start effective treatments and improve their lives.
There's a reason why you always have to make other lifestyle changes and do therapy alongside the medication in order for it to "work". And then, after all the lifestyle changes - oh would you look at that - you don't even need the medication anymore because your depression is cured! Best part is, there isn't even any withdrawals for some reason! Don't think about it! But the downside I've also seen people take a handful of medications, change nothing, and then get even more depressed because the magic pill isn't working.
People make fun of organised religion, then pay tithe and pray to the antidepressant and antianxiety God every morning. Go figure.
Wdym no withdrawal symptoms? Suddenly stopping SSRIs has pretty severe symptoms
It didn't for me or anybody I know. Maybe the doctor literally just gave us fake pills and everyone else got real pills lol who knows
That's the best case scenario.
The worst case scenario is that it's mostly placebo, and when it does work, it's just natural recovery; and, further, that the psychiatrists' prescription pattern is entirely based on "what's worked" in their personal history as prescriber which will, of course, be random.
Anyway, long term studies on the effects of most psychotropic drugs indicate that they are much more likely to induce dependence than to actually "cure" you.
I believed that for 30 years until I tried zoloft and experienced a sensation somewhat similar to that of psilocybin, which has also been linked to treating depression, and then I went "ohhh....." and stayed on it until the side effects wore off and yeah. It's not just placebo. I was wrong. I'm sorry to everyone on the internet I misled.
One of many studies concluding, "meh."
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(19)30366-9/fulltext
This... doesn't seem very meh?
That's actually pretty much spot on how it worked for me. My depression was cause of things in my life, and it didn't do much for that, but it did wonders for my anxiety, which made it easier for me to ask for help and fix my life. I used to be afraid of going into stores. I used to be afraid of pain, due to pain disorders I have. I couldn't have caffeine, or even chocolate, because even a little bit of stimulant made me too jittery and feel awful. I don't have so much fear anymore. I can eat chocolate again!
Most of those meds aren't intended to cure you. You're supposed to take them in conjunction with therapy to develop healthy ways of managing the disorder.
That reminds me of that joke about the pill that cures thirst. You just take it along with a cup of water, and voilΓ , the thirst is gone
Medical treatment for bipolar and schizophrenia is considered lifelong.
For depression, yes, there is one strand of thought it that pairs it with talk therapy, but often people are on the drugs for years.
Yes, much like diabetes someone with bipolar disorder or schizophrenia is going to be taking the medication their whole life. And much like diabetes, working with a medical professional will help them to identify lifestyle changes and coping strategies that allow them to eventually self-regulate their medical concerns, and they will only need occasional professional involvement.
Maybe in some shitty countries, but over here we ain't prescribing shit without a decent evidence base because the medical regulator is actually competent.
The studies for efficacy in the US are mostly short-term. Psychiatric outcomes in "shitty countries" uninfected with pro-medicine psychiatry are actually better.
You're claiming the US doesn't count as a shitty country when it comes to healthcare?
Not arguing much of anything vis-a-vis the US, but most of what gets approved here gets approved everywhere else.
I don't know of any credible evidence that my country's medical regulator has been captured by the pharmaceutical industry.