I'm going to suggest the Motif system, as it has Story, Character, and World emulators that might make it easier to run.
https://www.drivethrurpg.com/en/publisher/7970/thought-punks/category/38729/motif-framework
I have used this system for a solo game of Traveller and it worked quite well.
Yes, the story engine is the core system. It's primarily what I used for my solo game, as Traveller has enough other systems to fill in the world running. But I think the character engine might be simpler than using something like the Traveller 5 personals system if you truly need some randomness to how NPCs will react.