Danger Dust

Oxidative and nitrosative stress 

During the process of energy production, mitochondria produce highly reactive oxygen molecules known as reactive oxygen species (ROS). While ROS play a key role in the regulation of cell function, excessive levels can cause damage to cells and tissues.

ROS are normally kept under control by natural processes which remove them from them the circulation, but when an imbalance occurs ROS can be left to build up and cause damage in the body – a state known as oxidative stress.

Oxidative stress has been linked to many diseases, including Alzheimer’s disease, cardiovascular disease and cancer, and it has also been associated with ME/CFS. In fact, findings suggest that the “normal processes controlling free radicals are not working properly in patients with ME/CFS”.

Interestingly, the authors highlight that nitrosative stress – which occurs when reactive nitrogen species build up in the body – has also been identified in people with ME/CFS. Like oxidative stress, nitrosative stress has been linked to cell damage and disease.