this post was submitted on 21 Jan 2025
221 points (99.1% liked)

Science

7073 readers
85 users here now

General discussions about "science" itself

Be sure to also check out these other Fediverse science communities:

https://lemmy.ml/c/science

https://beehaw.org/c/science

founded 4 years ago
MODERATORS
 

Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.

top 40 comments
sorted by: hot top controversial new old
[–] Gullible@sh.itjust.works 61 points 1 year ago (1 children)

This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid

[–] nooneescapesthelaw@mander.xyz 7 points 1 year ago (1 children)

Obviously I understand what femininely turgid means but can you explain it just in case somebody else doesn't know?

[–] scarabic@lemmy.world 7 points 1 year ago (1 children)

ie: ladyboner, the old slip n slide, juices flowing, mine honeypot overfloweth

[–] nomy@lemmy.zip 3 points 1 year ago

Like a lil cashew down there.

[–] RobotToaster@mander.xyz 40 points 1 year ago (1 children)

The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.

[–] __nobodynowhere@lemm.ee 6 points 1 year ago (2 children)
[–] rickyrigatoni@lemm.ee 27 points 1 year ago

The hat man cleans your brain for you.

[–] RobotToaster@mander.xyz 7 points 1 year ago

Unknown, but it's an anticholinergic, and those are associated with dementia.

[–] flicker@lemmy.dbzer0.com 26 points 1 year ago (2 children)

I have ADHD. Without drugs, I only sleep during the day, and sometimes, I'll skip a day and feel like crap about it no matter what I do.

I mean without drugs. I used to be an all-natural whackadoo.

Nowadays I do drugs about it and I'm allowed to be a real human. Guess my brain will clean itself when I die.

[–] pelespirit@sh.itjust.works 9 points 1 year ago

Be careful about assuming that your drugs are what they're talking about. Yours sound like they're balancing you out. They could be cleaning out your brain. Make sure to look at the study carefully.

[–] ChadMcTruth@lemmy.world -2 points 1 year ago

you probably just need fresh nutrients

[–] anarchrist@lemmy.dbzer0.com 14 points 1 year ago (1 children)

I wonder if ketamine has the same effect, he asked apropos of nothing...

[–] metaStatic@kbin.earth 11 points 1 year ago (1 children)
[–] MossyFeathers@pawb.social 11 points 1 year ago

Actually maybe not? Iirc most "traditional" anesthesia basically knocks you down to the bare minimum of brain activity to remain alive and reliably regain consciousness (which is why being under anesthesia is usually a "blink and you miss it" ordeal, your brain isn't active enough to be aware that time has passed).

However, if I'm not mistaken, stuff like ketamine or nitrous don't do that, and sedate you in a manner more similar to natural sleep.

[–] workerONE@lemmy.world 11 points 1 year ago (3 children)
[–] Agent641@lemmy.world 6 points 1 year ago (1 children)
[–] rosa666parks@lemmy.dbzer0.com 2 points 1 year ago (1 children)

Then gets you really sleepy

[–] sunzu2@thebrainbin.org -1 points 1 year ago

Being knocked out is not sleep.

[–] TypicalHog@lemm.ee 3 points 1 year ago

Suppresses dreams and dreams are apparently good and needed for a healthy brain.

[–] sunzu2@thebrainbin.org 0 points 1 year ago (1 children)

Se thing as any other substance

Weed too

[–] workerONE@lemmy.world 1 points 1 year ago (1 children)
[–] sunzu2@thebrainbin.org 0 points 1 year ago

That shit don't last long enough?

[–] sunzu2@thebrainbin.org 9 points 1 year ago (1 children)

Alcohol and weed does the same thing, just because you are out. Doesn't mean you are sleeping.

Good to see this common sense being confirmed

[–] otp@sh.itjust.works 1 points 1 year ago

I wouldn't even call it common sense. I remember being taught like 20 years ago that we don't even know for sure why we need to sleep (aside from the fact that we get tired and sleep is pretty good at helping with that).

[–] peoplebeproblems@midwest.social 7 points 1 year ago (2 children)
[–] RvTV95XBeo@sh.itjust.works 7 points 1 year ago

That usually helps me sleep better too

[–] scarabic@lemmy.world 0 points 1 year ago
[–] some_guy@lemmy.sdf.org 6 points 1 year ago

Eff. I require sleeping pills. I guess I can look forward to a melted brain in old age.

[–] Hackworth@lemmy.world 5 points 1 year ago* (last edited 1 year ago)

You need healthy, natural sleep. Chew some valerian root and get more exercise.

[–] intensely_human@lemm.ee 5 points 1 year ago

If you want your brain to clean out waste at night, you need to be taking sweeping pills.

[–] TacoButtPlug@sh.itjust.works 5 points 1 year ago (2 children)

I wonder what melatonin does

[–] TypicalHog@lemm.ee 5 points 1 year ago (1 children)

It's a natural hormone brain produces that signals to the body that it's zzz time.

[–] TacoButtPlug@sh.itjust.works 2 points 1 year ago (1 children)

I love it for bedtime and it helps my autoimmune shit. Glad it's not brain bad.

[–] otp@sh.itjust.works 2 points 1 year ago

Aside from possibly becoming a dependency, I'd imagine it doesn't interfere with sleep quality. It's what builds up in your body to make you sleepy/fall asleep.

Too much might keep you groggy in the morning though.

[–] Agent641@lemmy.world 5 points 1 year ago (2 children)

Forget melatonin, I want to know wtf cheese is doing to my brain when I sleep on it.

[–] SirQuackTheDuck@lemmy.world 9 points 1 year ago

Probably just stick to the side of your head.

Have you tried eating the cheese instead?

[–] TacoButtPlug@sh.itjust.works 3 points 1 year ago (1 children)

Charlie Kelly... who taught you about Lemmy?

[–] DaCrazyJamez@sh.itjust.works 2 points 1 year ago

Im pretty sure cat food and spray paint shut down m9re than just the NREM cycle in the brain...

[–] Cephalotrocity@biglemmowski.win 2 points 1 year ago (1 children)

Apparently the water supply in my town is dosed with sleeping pills.

[–] pelespirit@sh.itjust.works 9 points 1 year ago

Honestly, it might be. When people pee, that toilet water goes somewhere.

Drugs found in Puget Sound salmon from tainted wastewater