Firefox

If you spend any time on YouTube sponsor block is handy

I still like my NoScript, sometimes I just take it as an indicator of who makes shitty sites.
If I end up on a site that's completely blank and it isn't important for me to interact with it, Ieave.
Surprisingly even news sites often load better than most others with NoScript disabling everything on them, I guess at the end of the day they still really need people to read them otherwise they'd become completely irrelevant?

I've seen complaints (Reddit I think?)that it just makes it cumbersome to do stuff when there are cascading lists of domain opening as you enable one, but if you're the kind of person that permanently whitelists all of them at that point, I don't think any amount of add-ons are going to save you, but I do like puzzles so I don't mind figuring out what needs to be toggled for site to work.

The big downside is making payments on sites with silly amounts of 3rd parties involved (Im looking at you Costco), but it's a bit better than it used to be when there was concern about getting charged twice, now it's more like...don't get charged and wonder why they didn't process your payment.

Edit: is it NoScript or ublockorigin that blocks ads on prime video? It's one or the other which is nice if you're watching something on pc rather than TV, I guess I should test.