Is that an animation error with Homer and his mug?
The Simpsons
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Right about now, you're probably saying, "Troy, basically every post starts with 'Guess the Episode', is that all this community is?"
To which I say you've got some attitude, mister.
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Discussion
Guess the Episode "Rules"
- Post a screenshot from an episode of the Simpsons. Frinkiac being a popular source.
- If posting a GIF the file size should be less than 1MB, otherwise it may not be animated.
- Easy, a screenshot any who's seen the Simpsons would get.
- Medium, a screenshot that would take a moment for most people to get.
- Hard, a screenshot that someone only gets after you explain it to them.
- Genius at Work, a screenshot that makes someone go, "Yeah, that's from The Simpsons, the one where the family does the funny thing".
These "Rules" aren't real, so if you think of something clever, do that instead.
I didn't notice but yes, it is. In the next frame or so Homer's hand is back behind the glass.

it's an empty glass
It's the episode where homer predicted the apocalypse. He Made a mistake the first time, so nobody trusted him, so only him could go to heaven.
Because of his mistake, Moe sold his bar that became a sushi bar, and at the end of the episode, Homer asks god to have bar's moe back to normal (and to cancel the apocalypse). This is the final scene / last supper.
Correct!

Joke is obvious, I think: Last Supper.