this post was submitted on 21 Feb 2026
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I’m about to take some myself in the next couple of weeks and would like to know the changes you’ve experienced upon taking them, what type you take, how long for, when you noticed a difference and what… etc

I have seen people’s posts but want to hear first hand if possible to really get an idea.

Thank you!

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[–] FRYD@sh.itjust.works 14 points 1 week ago* (last edited 1 week ago)

Four weeks in. Estradiol pills, 2mg, twice a day sublingually. At around two weeks I noticed my nipples had gotten bigger and much more sensitive and my skin is much softer.

Now four weeks in, I have the beginning of breast development, my chest occasionally hurts, I’m much more confident and a good bit happier and weight redistribution has started, but not much. My face looks a bit different. I get carded every time I try to buy alcohol (I’m 28 btw) and multiple bartenders and convenience store clerks have expressed astonishment at how young I look. I’ve gained nearly 10 lbs, my hips and chest are a bit squishy now when they were pretty bony previously. I’ve also been hungrier and eating more. My muscles are softer and more squishy now too, not quite atrophied, but I’m a very active person. They’re less defined even when I flex now.

It’s apparently hitting me much faster than is common, but I have a friend who had a similar timeline and the doc seems to think it’s fine.

Edit: I forgot to mention that my dreams are different now and my libido has dropped considerably as well.