Summary (2 minute read): https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.27.1_supplement.127.4
Linked to the title is the full study. Image is figure 2 from the study.
this post was submitted on 29 Jan 2025
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Metabolic Health
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The data for this RCT was collected between 1966 and 1973 and stored on magnetic tape. As it was at the height of promotion of vegetable sourced fats over animal sourced fats and the data showed clearly that substituting vegetable oil (safflower oil) and margarine (safflower based, free of trans fats) caused an increase in risk of death, risk of cardiovascular event, risk of coronary event.
I wonder how this would have changed things if it was published in 1974.
The impact would have been huge! The narrative would have to be nuanced, and further understanding of LDL's full mechanical roles would be illustrated earlier!