this post was submitted on 13 Dec 2024
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World-leading scientists have called for a halt on research to create “mirror life” microbes amid concerns that the synthetic organisms would present an “unprecedented risk” to life on Earth.

The international group of Nobel laureates and other experts warn that mirror bacteria, constructed from mirror images of molecules found in nature, could become established in the environment and slip past the immune defences of natural organisms, putting humans, animals and plants at risk of lethal infections.

Many molecules for life can exist in two distinct forms, each the mirror image of the other. The DNA of all living organisms is made from “right-handed” nucleotides, while proteins, the building blocks of cells, are made from “left-handed” amino acids. Why nature works this way is unclear: life could have chosen left-handed DNA and right-handed proteins instead.

The fresh concerns over the technology are revealed in a 299-page report and a commentary in the journal Science. While enthusiastic about research on mirror molecules, the report sees substantial risks in mirror microbes and calls for a global debate on the work.

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[–] ieatpwns@lemmy.world 57 points 1 year ago (3 children)

Ahh yes, man made horrors beyond our comprehension

[–] Tudsamfa@lemmy.world 18 points 1 year ago* (last edited 1 year ago) (1 children)

Proteins and DNA and their mirrored counterparts behave like the Tetris L and ⅃ blocks, basically the same but you cannot rotate them to fit in a hole meant for the other. Fitting in holes is, somewhat literally, how most processes of life work on the sub-cellular level.

Processes like the immune system. And if an experimental microbe from mirrored DNA doesn't fit in the holes your immune system uses to identify things, because all the proteins curve the wrong way, there's no telling how it behaves, even if the unmirrored version is one of the most studied organisms. And it's not just your immune system, it's every living things' one. And 1 microbe alone is a potential pandemic.

I am no expert, but I hope the horror is comprehensible now. If not, I imagine minuteEarth's video on mirrored molecules is basically the same reasoning here, with the caveat that mirrored DNA tends to make more of itself.

[–] ieatpwns@lemmy.world 11 points 1 year ago (1 children)

The incomprehensible part was that we don’t know how bad things can get if this stuff got out into the wild. I got the chiral parts lol thanks for the further explanation

I get the fear but what about those of us that want a Symbiote-suit?

[–] rickyrigatoni@lemm.ee 4 points 1 year ago (1 children)

I can comprehend this one perfectly, actually.

[–] Tudsamfa@lemmy.world 1 points 1 year ago

It really is more of a fear of the unknowable than a horror beyond comprehension, isn't it?