Honestly, look into pain killer studies. We still don't know how many of them work even though we know that they do work. The brain and nervous system is weird.

[–] Bohne93@feddit.org 12 points 1 week ago (2 children)

Anesthesia, we have no idea how, just that it works

[–] MalReynolds@slrpnk.net 6 points 1 week ago (1 children)

At the end of the day, enough empirical data over a long enough time frame will have to do, especially if there are no alternatives. Sure do like me a good mechanism though, especially for new things, gives a clue as to long term side effects.

[–] ChunkMcHorkle@lemmy.world 2 points 1 week ago

I heard that in Fillion's voice, lol. Shiny.

[–] Natanael@slrpnk.net 3 points 1 week ago

Genuinely, we're better at preventing memory formation and experience of pain than actual sedation. Patients can be cognitively present, and the reason they're not traumatized from a experiencing a surgery is that we're preventing the experience from leaving a mark on the brain

https://pubmed.ncbi.nlm.nih.gov/40626585/

[–] exasperation@lemmy.dbzer0.com 4 points 1 week ago (1 children)

Honestly, look into pain killer studies. We still don't know how many of them work even though we know that they do work.

Tylenol (acetaminophen/paracetamol) is one of the most used painkillers and we still don't know the mechanism of action.

[–] Tollana1234567@lemmy.today 1 points 1 week ago

but it tends to be weaker than the nonselective cox inhibitors, otc nsaids.