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Hard to say. Probably one of the poles of inaccessibility or point nemo, as noted. But I would also consider shipping lanes bringing sailors nearby.
Human history is so long that real global travel is very, very recent, so I don't think you need to consider "well first horses then ships then cars then planes" because it all happened fairly quickly.
If you wanted a true answer, you could probably take a human migration map by era. Because the recent global travel would have such a comparatively light weight, the thought experiment math suggests it's one of those points mentioned.
By population, most humans lived after the bronze age collapse, and like 20%+ after the industrial revolution. We estimate only a bit over 100 billion humans in total.
So really I think you can ignore anything pre-industrial without too much loss. Anything preindustrial humans got to, nowadays many more can get to, so those areas would be densely covered.
But really since a single person can ruin a point, you also need to consider all weird stuff.
Point Nemo, people could have gotten to more frequently since maybe 500 years ago with better ships. To consider would be roughly were sail ships would sail, snd where they could end up with any number of accidents. Then the same for steam ships, and modern container ships.
Weirdnesses would be survey ships for example. Anyone mapping the ocean floor, or looking for resources to mine, will very strategically cover an entire area with lines maybe 10-20km appart. The same happens with survey planes.
And who knows where a nuclesr sub might cross the pacific between various start and end-points.
Finally there is the worst nightmare, explorers.
Your guess for the point: remote hard to get to location.
Consequence: Point becomes famous, 50 people will risk their life to ship themselves to the south pole, the tallest mountain in antarctica, or point nemo.
So anything that has a name and is known to be remote is probably out.