Antibodies that block interleukin-10 (IL-10), a cell-to-cell messenger that normally acts as one of the body’s key controls on inflammation, effectively remove the immune system’s natural ‘brake’ on inflammation, allowing inflammatory responses to continue unchecked.

[–] laranis@lemmy.zip 27 points 3 weeks ago (4 children)

Thanks for the TLDR. As a layman, that sounds like they've discovered the mechanism by which it happens, not the cause as the title suggests. Why is there an imbalance of those antibodies in the first place?

I know they'll come up with some drug that blocks those antibodies from interacting with IL-10 and it will be great for those who suffer from this. But something has to be the cause, right? Something that itself can be addressed?

[–] jam12705@lemmy.world 17 points 3 weeks ago (1 children)

In the article they explain its a certain genetic marker thats activated causing the imbalance.

[–] adespoton@lemmy.ca 4 points 3 weeks ago (1 children)

Yes, but what’s the activation trigger?

[–] jam12705@lemmy.world 1 points 3 weeks ago

Don't have that answer yet

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