Well, I prefer Arch, but a major factor in that preference is the fact that some software I rely on for my work is very hard to find on other distributions and that creates unnecessary hassle for me.
Fedora and Debian/Ubuntu are both pretty solid choices for a base OS, but Fedora might be more robust in the long run.
The main example I'm thinking of is SageMath, which is available in the default Pacman repositories but is not maintained as a package in Debian or Fedora.
You can build it from scratch, and I've done this before on Fedora systems, but it's much easier to install the latest version with a single command.