Sal

joined 4 years ago
MODERATOR OF
 

Abstract

Psychedelics can profoundly alter consciousness by reorganizing brain connectivity, producing acute experiences that shape lasting psychological change. Psychedelic dynamics are commonly described as desynchronized or entropically disordered, yet the brain organization underlying self-dissolving and boundary-dissolving experiences that participants often report, and how context shapes that organization, remain unresolved. To address this, we acquired the largest single-site psychedelic neuroimaging dataset to date. Sixty-two adults underwent functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) during rest and naturalistic stimuli (meditation, music and movie), before and on the day of psilocybin administration (fMRI ~ 80 min post-dose; EEG ~ 150 min post-dose). Half ranked the experience among the most meaningful of their lives. Here, using machine learning to represent the brain dynamics of each individual as low-dimensional trajectories, we show that psilocybin reorganizes brain activity into structured, context-sensitive patterns that co-vary with the quality of subjective experience, revealing a latent order missed by time-averaged measures. Networks that ordinarily segregate internal and external processing integrated, producing cohesive context-aligned trajectories in participants reporting the felt experience of being continuous with, rather than separate from, the environment, a state we refer to as embeddedness. The strength of this context alignment scaled with both the depth of self-dissolving and boundary-dissolving experience and the next-day mindset change. Our findings recast apparent disorder as latent organization aligned with context, linking neurobiology to subjective experience and behavioural change.

[–] Sal@mander.xyz 3 points 1 month ago

It’s especially disappointing because he chose to remove real science in favor of his own political bias.

That was not why I removed it. I removed it because I thought that many users reported it as racist/transphobic. If that many people report it as racist/transphobic, that is usually enough for me. The problem is that it was a comment to the post what was being reported, not the post itself, but I was processing the reports quickly and I made that mistake.

That said, since you brought up my political bias, I don’t mind stating my actual views openly.

Here are some biases that come to mind:

  • I weigh a local community's interests much more heavily than a business interest
  • anti-nationalism bias
  • biased towards policies that aim to reduce global inequality and minimize environmental damage, even when they come at the expense of the local population
  • biased towards immigration policies that provide mobility
  • anti war, anti violence
  • pro privacy
  • pro drug legalization

When it comes to gender identity: To me, it is common sense that everyone deserves respect, medical professionals should be the ones deciding, based on the best available evidence, what care is appropriate for their patients, and people should be able to make their own informed choices. I want everyone to live their best possible life and if someone identifies in some way, then accepting that and treating them how they want to be treated takes minimal effort and is basic respect. So, I can appreciate that it is an important political issue, but it is just so frustrating that it is an issue at all. Political discussions around gender identity often start from assumptions that I reject, and so I don't see the point of engaging the discussion at that level. If you want to know my bias on that, it is: don't use politics to regulate how medical professionals can help people, and respect everyone. I’m sorry to people who care deeply about sports, world records, and gendered bathrooms, but to me those are secondary issues. Basic human dignity comes first. The edge cases, legal loopholes, medical malpractice or abuse, and sports regulations can be dealt with after that. What I often notice is that science gets pulled into debates that already rest on assumptions I reject.

An example that comes to mind is reading, many years ago, that gay penguins show that being gay is natural, and that this somehow supports the argument for gay marriage. I never liked that reasoning, and I find that having a back-and-forth about whether being gay is natural or not is counter-productive. This type of argument implicitly accepts an appeal to nature, which I reject.

So, the way I see it, what looks like a purely scientific disagreement is often not resolvable by science alone, because the actual disagreement lives underneath that, in different values and basic philosophical assumptions. It is extremely difficult to moderate a polarized discussion when science is used as if it could settle arguments that actually go much deeper, into values and what people think is right or wrong.

This is how I see it.

[–] Sal@mander.xyz 3 points 1 month ago* (last edited 1 month ago)

I just encountered the type of example that I often struggle with, and so that is a good opportunity to describe my train of thought.

If you open the !academia@mander.xyz community right now, this is what you will see:

Post #1 has 'Trump' in the title, which is causing Trump to be featured at the top of Mander's front page. Posts 2 and 3 are about a highly polarizing subject that has become politicized, and the fifth post is about the pentagon cutting federal funding - which is also highly political.

These are true:

  • These posts are political
  • These posts are highly relevant to an 'academia' community
  • I have not been good at creating guidelines for the community, as the sidebar is empty

So, the options that come to my mind are:

  1. Accept politics in general whenever relevant
  2. If no one reports, then no one minds, so just let it go. If someone reports, remove it
  3. Create some general rule that if 'White House' or 'Trump' is in a title, remove it. This at least keeps posts with ‘Trump’ in the title off Mander’s local page, which is a common source of annoyance for me, and I suspect for others as well.
  4. Remove the Academia community because it is a spot where politics infiltrate. I do not like this solution because politics infiltrates on many valuable topics, not only one.
  5. Define a set of guidelines that creates a perfect filter and make the effort to implement it fairly. This is difficult both at the design stage and the implementation.
  6. Apply a very strong politics filter and if I can even smell a political angle, remove it. This approach likely invites pushback, which I cannot reply to with more 'that's the rule, have a nice day' unless I want to spend all my energy discussing. I have considered this because I think that, even if unpopular, there is a minority with whom this concept would resonate and so they would appreciate having that space.

There are many more options that I did not list. I just wanted to give you a concrete example of my reasoning.

I want topic communities to remain useful even when their subject intersects politics, but I also want Mander to be a space where political discourse does not continuously colonize unrelated interests. I don't know how to draw a boundary that is both predictable and enforceable.

[–] Sal@mander.xyz 6 points 1 month ago

They say it is edible but the whole growing out of the sack grossed me out on this one so I passed.

... Yeah, that is understandable. Great find! And I like the picture of the gills a lot

[–] Sal@mander.xyz 8 points 1 month ago

Bonus birbs

[–] Sal@mander.xyz 6 points 1 month ago

Yeah, I'm sorry. I usually try to not be this careless and it is very unlikely to happen again (at least this specific form of mistake. I am open to making new kinds of mistakes in the future).

 

Set up my camera in timelapse mode next to a bird feeder. This is my favorite illegallysmolbirbs capture so far. I'll keep trying.

[–] Sal@mander.xyz 4 points 1 month ago

Politics is a tricky subject and nebulously saying no politics isn’t a good strategy because everything is political.

For that reason, attempting to create a formal 'politics' filter is likely to be counter-productive. In general, I apply common sense, which is largely subjective by definition. The way I balance this is that I always err in the side of not removing things. Just want to emphasize that the reason used to mistakenly remove this post was not related to the general politics rule. I mistakenly thought that the post was reported by multiple people.

So I think a better goal would be to target the political behaviors that hurt people

My logic for setting the scope as I did is the following:

  • The internet is flooded with posts about politics, and especially so with US-centered politics (and I am not from nor live in the US)
  • Politics and topics that have become polarized by politics tend to be difficult to moderate

So, because my instance's focus is science and nature, I decided to make one of my instance's value propositions: If you choose this instance your Local feed will not have politics in it. Note, that, one has access to 'All' and one can also access the instance's communities from other instances. So, in my view, an instance that offers such a value proposition is a healthy component of the ecosystem - and easier for me to moderate.

I do agree that trying to come up with some better writing and guidelines that transmit the core idea while making it fairly enforceable would be good. I have said a few times in the past that I would do this, but I still don't really know how. So I keep reading what people suggest. Thank you!

[–] Sal@mander.xyz 8 points 1 month ago

Yes, of course! Moderators are gold. I need to make a better effort at recruiting.

[–] Sal@mander.xyz 14 points 1 month ago (2 children)

Oh.

I checked the reports, and what I see is a sequence of 6 reports reporting hoohoohoot's comments. I do not have a vivid memory of the moment as I was just processing the back-log, but what must have happened is that In haste I interpreted this as 6 independent reports of the post, not noticing that the reports were of the comments, and so when I opened the post I was operating on what I mistakenly thought was a very high signal. I still did not want to claim 'transphobia' in my reason without verifying that, so, as I explained, I used the loophole as an excuse.

Usually, if this would really have been 6 independent reports of the same post, removing it would have been very likely the correct move. This contributed to why I was careless.

Here are 4 of them, I removed the names because these are not false reports:

[–] Sal@mander.xyz 51 points 1 month ago (11 children)

You are right, I did not make the right call on this one.

I have been neglecting the instance very aggressively due to being busy this summer. I was scanning through the report backlog and this post was reported for 'transphobia'. I skimmed through, clicked on a whitehouse link that said "RESTORING BIOLOGICAL TRUTH TO THE FEDERAL GOVERNMENT" in big letters, and instead of doing more due-diligence I applied a rule that I rarely apply as the discriminant to process it quickly. The rule being, as you mentioned, that the 'Science' community is meant to be for discussing science itself. It is a meta-community.

In practice, I stopped enforcing this rule for the most part, which means that in this case it was an excuse I used to process the report quickly without needing to validate whether I personally think it is 'transphobia' or not.

Sorry

Some things:

  1. I make mistakes, if you send me message I will usually correct it or at least explain my reasons.
  2. When I get reports such as 'transphobia' or 'racism', I automatically bias heavily my decision towards the reporter because I can easily miss something in my personal analysis.
  3. Very often the explanation between 'why was A removed and B allowed to stay' is that A was reported and B was not.
  4. My stated intention is to minimize politics and polarizing content, but this has proven difficult to achieve in practice
[–] Sal@mander.xyz 0 points 1 month ago (1 children)

Hey, sorry for the slow response. Feel free to appoint me as a mod until someone else wants to fully take over so that you don't feel pressured to hold that spot for longer

[–] Sal@mander.xyz 0 points 3 months ago

Interesting... Good to hear!

[–] Sal@mander.xyz 6 points 3 months ago (3 children)

Sorry, I am in the process of moving and have not been able to keep a close eye, and the disk filled up. I have increased the disk size now, but I see some errors with the images. I need to sleep now but in the morning if it is not fixed I'll figure out what is happening.

 

Abstract

Electrochemical production of fuels from solar energy, commonly referred to as solar-fuel production, is a key technology for converting abundant yet intermittent solar energy into a stable energy source. Typically, this process employs an electrolyzer coupled with photovoltaic (PV) cells through an electronic maximum power point tracking (MPPT) system. Here, we propose a chemical MPPT system, integrated directly into the electrolyzer, to enable stand-alone and unmanned liquid solar-fuel production with stabilized concentration changes from sunrise to sunset. The working principle of the MPPT system is derived from the impedance and heat-transfer properties of the electrolyzer, which incorporates a solid-state electrolyte exhibiting ionic resistivity with a negative temperature coefficient. Application of the mathematical model to a real electrolyzer energized by a commercially-available monocrystalline-Si PV panel for producing pure aqueous formic-acid solution demonstrated a high utilization factor (85%) of PV energy and a 2% external solar-to-formic-acid (eSTF) energy efficiency for 0.1 kg of formic acid from pure water and carbon dioxide (CO2) during daytime operation, all without the use of a conventional electronic MPPT system.

 

Abstract

The origin of life (OoL) is a fundamental and long-standing scientific question. Although a variety of plausible hypotheses had been put forward, how life began on the prebiotic Earth from a pile of prehistoric inert chemicals (gases) is still a puzzle to us. Here, to unify the existing hypotheses to cover the entire scenarios, the author proposed the “nanozymes hypothesis” of the OoL on Earth, in which natural mineral nanozymes (MN-zymes) and their later upgraded organic/inorganic hybridized nanozymes played multiple key roles in the initial emergence of life molecules, especially in the manner of “inorganic photosynthesis” under primitive Earth conditions. Under the hypothesis framework, proteins, DNA, and RNA might emerged near-simultaneously, as a result of the diversity of nanozymes and catalyses, and multiple physical and chemical key roles of the MN-zymes. Besides nanozyme aspects, several fundamental and key issues on the topic are briefly discussed and several essential elements and conditions for the natural selection and survival of life molecules are proposed.

17
submitted 3 months ago* (last edited 3 months ago) by Sal@mander.xyz to c/aboringdystopia@mander.xyz
 

Hello all,

This community will be removed from the instance in the near future because it is unmoderated, does not align with the instance's focus, and frequently introduces political content into the local feed, which is contrary to the instance's goal of minimizing political content.

Alternative versions of aboringdystopia are available on other instances:

!aboringdystopia@lemmy.world

!aboringdystopia@lemmy.ml

!aboringdystopia@lemm.ee

I would prefer locking the community to avoid losing visibility of the posts, but unfortunately locking a community is not an available feature.

EDIT: As Trying2KnowMyself pointed out below, it is possible to restrict the community to moderator posts. So, I have done that instead to preserve older content.

9
VIII, by Era (eramusicofficial.bandcamp.com)
 

Very happy and surprised to see a new release from Era!

The song 'Not You Again' is my favorite so far.

 

Summary

Scientists in South Korea have discovered that a probiotic bacterium found in kimchi may help the body flush out tiny plastic particles before they can build up in organs. In lab tests, the kimchi-derived microbe clung tightly to nanoplastics even under conditions designed to mimic the human intestine, where other bacteria quickly lost their grip.

 

Abstract

Photochemical upconversion has several potential applications in optoelectronics. However, there is yet to be demonstrated a rational approach to high efficiencies in nanoscale solid-state devices. Here we demonstrate that the liquid triplet fusion medium, 9,10-bis(n-octyl-diisopropylsilylethynyl)anthracene (NODIPS-An), which behaves as a solid on excitonic timescales, can achieve high-efficiency upconversion on the nanoscale. Owing to its amorphous structure, there are highly-coupled sites that trap upconverted states and prevent the back transfer that plagues nanoscale upconversion systems. With NODIPS-An filling the pores of a sensitized alumina nano-scaffold, we achieve an absolute photon upconversion efficiency of 8.2(4)%. The majority of efficiency losses are attributed to fluorescence and triplet energy transfer yields, and thus the self-trapping of excitons within the triplet fusion medium is demonstrated to effectively prevent the back transfer of excitons to the sensitizer. Strategies are proposed to improve the fluorescence yield and triplet energy transfer to pursue higher efficiencies in nanoscale solid-state photochemical upconversion devices.

 

Abstract

Coumarin-based derivatives are recognized as tunable photonic building blocks due to their strong light–matter interaction and relevance for both linear and nonlinear optical applications. This work presents an investigation of the linear optical properties and multiphoton excitation response of four derivatives coupled with benzothiazole and benzimidazole moieties. The compounds 7-diethylamino-coumarin-benzothiazole, 6-bromo-coumarin-benzothiazole, and 7-diethylamino-coumarin-benzimidazole exhibit nearly identical absorption maxima (∼423–428 nm) and emission peaks (∼485 nm), while displaying pronounced differences in molar absorptivity and ground to first excited-state transition dipole moment (μ01). The 7-diethylamino-substituted derivatives show enhanced molar absorptivity (∼5.3 × 104 L mol–1 cm–1) and larger transition dipole moment (μ01 ∼ 8.1 D) compared to the bromo-substituted (μ01 ∼ 5.5 D). In contrast, 7-hydroxyl-coumarin-methyl-benzimidazole exhibits a distinct spectral signature characterized by a larger Stokes shift and lower molar absorptivity, with an intermediate μ01 ∼ 7.0 D reflecting a different electronic balance within the conjugated framework. Multiphoton excitation experiments using femtosecond laser pulses demonstrate efficient two-photon (800 nm) and three-photon (1200 nm) excited fluorescence for all derivatives. Remarkably, the hydroxylated derivative combines an exceptionally high fluorescence quantum yield (∼48%) with a measurable excited-state lifetime (∼3 ns), identifying it as the most promising candidate for bright photoluminescent probing under one-, two-, and three-photon excitation.

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