I'm over 6500 hours.
I play the game like Sims with shooting. I'm most interested in settlement building. I might put 100, 200 hours in a play through and never touch the main quest line, and never go get Preston and them.
Nuka World is Open Season the instant Gage opens the door.
Far Harbor, I'll collect poor, confused Masumi and grab the settlements. I run the main quest, and the Dima memory game is fine with me, because I just use Place Everywhere to aim the green beam at the targets, which completely bypasses the final puzzle.
I used to run with Cait almost exclusively, but these days, I've been running with Piper, Nat, and Dogmeat. I wish vanilla had multiple companions, I'd love to hear Piper, Cait, and Currie fight over me.
Nat Companion: https://www.nexusmods.com/fallout4/mods/31774