Danger Dust

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A community for those occupationally exposed to dusts, toxins, pollutants, hazardous materials or noxious environments

Dangerous Dusts , Fibres, Toxins, Pollutants, Occupational Hazards, Stonemasonry, Construction News and Environmental Issues

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Comprehensive interrogation of synthetic lethality in the DNA damage response (www.nature.com)

submitted 2 weeks ago by [email protected] to c/[email protected]

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Our DDR interaction map identifies numerous synthetic lethal relationships that could be exploited in cancer therapy. Many already link established cancer genes and existing small-molecule targets and thus are readily actionable. We anticipate that exploration of our dataset will define more cancer-specific vulnerabilities that could translate into clinical benefit in patients.

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