me_irl

You are being downvoted because you are basically saying that if you relate to the joke, there's something wrong with you and you need help.

That is incorrect, and kinda offensive. You made a lot of people feel like you think they are fucked in the head.

What healthy introvert would claim a non-descript activity would put them out of interacting with anyone for days?

It doesn't. I don't have a panic attack if someone walks up to me and starts a conversarion, or have trouble interacting with people for work.

The joke doesn't have the person hyperventilating, simply turning someone down in a humorous paraphrased way, for a reason that is quite common. "I just socialized, not in the mood for more."

Learning to turn down requests to socialize in order to ensure you even get any alone time is about as relatable as it gets for an introvert.

If I just spent all weekend hanging out with a friend playing video games, and another friend then contacts me during the week to ask about the next weekend, I'm likely to turn them down because I want to have the following weekend for myself.

You think the joke is about anxiety, as if the writer thinks in-between meeting people "introverts" suffer some kind of break-down they need to overcome, which you acknowledge they don't. But the joke matches just as well with the way healthy introverts learn to manage how much time they spend around people, vs. alone.