this post was submitted on 28 Nov 2025
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Public Health

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There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests - Ars Technica (arstechnica.com)
submitted 1 month ago by otters_raft@lemmy.ca to c/publichealth@mander.xyz
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In trial, 82% saw weight rebound and cardiovascular health reverse after withdrawal.

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[โ€“] SuperNovaStar@lemmy.blahaj.zone 5 points 1 month ago

From what I understand, the "set point" for the hormonal triggers that decide whether someone stores fat or burns it are out of whack.

So someone might be so calorie-deficient that it becomes a serious issue, and yet their body is still trying to store fat instead of burning it.

This makes losing weight a lot harder and it's a lot more miserable for them, as opposed to someone who can just eat a little less and their body will smoothly transition over to burning fat to make up the difference.