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Are there ways to boost/strengthen the immune system without triggering inflammatory pathways? (sh.itjust.works)

submitted 2 weeks ago* (last edited 2 weeks ago) by AcidiclyBasicGlitch@sh.itjust.works to c/askscience@lemmy.world

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If somebody was having issues with a weakened immune system, and also dealing with a chronically higher baseline level of inflammation, are there any known ways to strengthen the immune system while reducing or at least not increasing baseline inflammation? Is that even possible or is some level of inflammation unavoidable?

Would it depend on the specific inflammatory factors that are already causing the higher baseline response?

I know there's some research about running reducing inflammation, but it also triggers some inflammation? Is the acute inflammation triggered by running tied to longer term reductions in inflammation?

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[–] AcidiclyBasicGlitch@sh.itjust.works 2 points 2 weeks ago* (last edited 2 weeks ago)

Yeah but not every anti-inflammatory is going to inhibit NF-kB equally, so having something to target with inhibition is more helpful than just advice to avoid inflammation.

https://pubmed.ncbi.nlm.nih.gov/15489888/

Overall these results indicate that aspirin and ibuprofen are least potent, while resveratrol, curcumin, celecoxib, and tamoxifen are the most potent anti-inflammatory and antiproliferative agents of those we studied.

You’d be operating on a hunch, essentially. Though I will say that your unusually nondescript and broad symptoms do seem roughly in line with what I would expect from TNFa signaling.

Unfortunately an educated hunch is about as much as I think I can expect as of now bc the only doctor who isn't just dismissing me is kind of at that point, and since he can't figure it out, he's open to suggestions.

And also having TNF-a levels tested isn't anything somebody has suggested previously. It took me going back and forth between March and April to even get in to see an allergist to measure my tryptase levels bc I assumed it was histamines. Turns out it wasn't.