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Vitamin C/ascorbic acid overdose for a short period.
Most people simply don't consume enough VitC in their daily lives, which affects the immune system, reducing its efficiency.
VitC is also pretty much the safest vitamin to overdose on - any surplus gets flushed out with your pee.
Whenever I start feeling sick, I start doing 4-5000mg a day doses, and keep doing 1000mg a day once I feel okay, for at least 2-3 weeks.
It doesn't as much "kickstart" your immune system as bring it back to peak efficiency, but for most who don't consume enough VitC, it can act like one.
I've read a study a while ago that compared vitamin intake effect on immunity. Additional VitC didn't do a thing, while B-complex actually had a measurable effect.