this post was submitted on 24 Sep 2025
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What drug is Tylenol because I always just assumed it was an antihistamine but apparently it's a painkiller?
It's just the most popular American brand of paracetamol/acetaminophen/APAP. It's also the only name for the drug that our President knows how to pronounce.
Lol yes, it’s a painkiller haha. Fairly mild, too, but usually the extra-strength version is what you’ll get after surgeries and stuff.
Benadryl is the kleenex of anti-allergy meds.
Don’t take Benadryl (diphenhydramine). Shit would never be approved for use if it were invented today. It fucks with your brain, messes with your reflexes, and is correlated strongly with dementia.
Second and third generation antihistamines work better and are non-drowsy.
benadryl should have been pulled years ago if the FDA wasn't a total fucking joke. And tylenol should be controlled.
Fair enough. I don’t take it, personally, though.
I used to, until I learned more about it.
One of the things that finally made me realize how potent it is: pilots aren’t allowed to fly for at least 60 hours after taking anticholinergics like diphenhydramine (Benadryl) or doxylamine (another first-gen antihistamine marketed as Unisom, and is also the thing in NyQuil that makes you drowsy).
Dang!
Tylenol is an extremely common and successful brand of pain relief medicine sold until very recently by Johnson & Johnson. The active ingredient is N-acetyl-para-aminophenol. This has been variously shortened to Acetaminophen, Paracetamol, or indeed Tylenol. Other medicines are sold under the Tylenol brand, such as Tylenol PM which is Acetaminophen and Dyphenhydramine (the drowsiness medication with a side effect of allergy relief that powers Benadryl and Sominex).
Here in Europe I've only ever seen it sold as paracetamol, and it tends to just be generic supermarket brand. Looking in my medicine, random keys, and elastic bands draw (everyone has one) even my allergen medication is just sold as antihistamine, with no branding.
The generic term used in the United States is Acetaminophen. Europeans don't know what that is, Americans don't know what Paracetamol is, they're the same thing. Generics are available but brand name Tylenol is ubiquitous here.
Tylenol is a brand that is old enough to be from a time before trademark law had been abused to death, back when a brand name meant you know who makes this. That idea is even more fundamental to American culture than freedom of speech but it got smothered in bed first.
Acetominophen, an analgesic (for pain) and antipyretic (for fever). It's not an antihistimine.
I have never used it, and never will. Far too toxic on the liver and blocking fever is a bad idea during infection.