“Alcohol is a mild poison” has been a house rule within my extended roleplaying circles for a long time. It fits well into almost any setting or metaphysics, and allows you to do interesting things with intoxication.
This comic follows on from the Previous comic which will almost certainly provide context.
You can follow this comic series from the start Here. Make sure to start at the bottom (oldest comic) and work upwards.
Didn't know these were on Lemmy! Love it!