For example, opioids like morphine provide effective relief from chronic pain, but people quickly develop tolerance to such drugs and the only option is to increase the dose, which can lead to addiction and, later on, withdrawal risks.
This is not even how opioids lead to addiction. They are antagonists of endorphin receptors. On another note, AFAIK tolerance and addictiveness are separate aspects of psychoactive substances, not causally related as implied by the article.
It makes me wonder, in the aftermath of an opioid epidemic created by corporate greed, why some people would try to "fix opioids" in that regard.