Not quite the same thing, but I really don't like the ISO (International, what a lot of European use) QWERTY layout compared to the US one. It's not unusable or anything, but...
I wish that ISO would make some new layout that starts from the layout from US ANSI and then stuffs the European-specific symbols somewhere on the keyboard.
And while I'm dreaming, I'd like that layout to physically swap left control and Caps Lock, so that I don't have to go swapping it in software everywhere.
And to get rid of Menu and Right Windows and replace it with Compose which is, I think, by far the most-preferable way to get access to a substantial additional number of characters. AltGr or Option permits for a small number of additional characters and is harder to remember for occasional use. The Windows Alt-numpad scheme is also much harder to remember, as is the GTK Control-shift-u convention.
I also don't use right Control, but I can believe that somewhere out there, someone gets actual use out of it and needs it somewhere comfortable, so I won't complain about that.
Actually, what I really want, which would solve the above in an even better fashion, is for laptops to use modular, standardized, replaceable keyboards so that I can just buy whatever keyboard I want and slap it on the thing. With external keyboards, as on desktops, the selection is much better.
EDIT: I'd also add that I've seen numerous European users saying that they also prefer the US ANSI layout over the ISO layout, so it's not just me being US-centric, and OP has a comment even saying so themselves in this thread. But if you just use stock US ANSI, then you don't directly get access to the extended Latin set, which you want in Europe. Though Compose can do that, and OP is, like me, also wanting Compose on his keyboard...