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According to the DSM-5, the diagnostic criteria for gender dysphoria include a marked incongruence between one's experienced or expressed gender and their assigned sex, lasting for at least six months, manifested by at least two of the following: a strong desire to be rid of one's primary and secondary sex characteristics, a strong desire for the primary and secondary sex characteristics of the other gender, a strong desire to be of the other gender, a strong desire to be treated as the other gender, and a strong conviction that one has the typical feelings and reactions of the other gender. Key points about gender dysphoria diagnosis: Significant incongruence: There must be a noticeable difference between the individual's experienced gender and their assigned sex. Duration: Symptoms must be present for at least six months. Multiple criteria needed: A diagnosis requires experiencing at least two of the listed criteria. Distress or impairment: The incongruence must cause clinically significant distress or impairment in social, occupational, or other areas of functioning.