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Depends which meds, most of those have rather subtle effects, especially ones ment for psychological issue, it's oftentimes even questionable whatever those work or not. Ones ment for physical ailments do have more noticable effects.
Like, long release ADHD med(concerta) was rather useless against ADHD, but max dosage did rise heart rate and gave me sweati palms.
Fluoxetine for depression didn't do anything.
Pain meds are obvious enough.
Testosterone has some mental effect from hormonal fluctuations and long term physical effects are good, within medical dosages.
Cialis has a minor physical effect, but no mental effect.
Rocutane has no mental sides and minimal physical side effects.
Funny you said Concerta did nothing for your ADHD, it worked for mine at high dose but at the cost of making me 1000x more stressed and irritatable lol.
Shoutout generic Vyvanse for just working
People are different, the only thing it affected was heart rate and sweaty palms which were directly linked to dosing, for fun i did try 2-3x over max dosages as well.
Biggest effect it had was on my wallet as the max dosage was 100€+ and absolutely no government aid. That was pretty much the last straw in looking for help with my ADHD. For that amount + therapy 80€ per session. I can handle ADHD, at least that's cheaper. That was years ago, prices have rose significantly since then.