Space

Out of interest I extracted the transcript of the video (watching was out of the question, >3 h 😯) and went over the summary.

Basically three main topics they seem to cover:

1. String theory in its present form is crap/is sound: Both sides have valid points here, my personal gut-feeling would actually be slightly on the side of the critics (Sabine is not the only one).
2. Scientific academia has a problem/is good as it is: From my personal experience (I am involved with partly government sponsored research and academic people, but in applied sciences) Sabine might actually has some valid points here. But also no acceptable solutions while being somewhat over the top in her expressions. As mentioned, I tend to ignore that content of her because of that.
3. Possible financial dependency on billionare oligarchs, possibly influencing her content: Speculation, but could well be. She published some weird stuff a few months ago that could originate there.

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So, while points 1. and 2. seem nothing to bother about, the third point actually might be something to keep in mind. But this is true for basically all youtubers beyond the hobbyist stage, with some notable exceptions, like the TLDR channel, that try to be as transparent as possible regarding their finances.
In most cases you just don't know what hidden agendas exist, mainly because of financial pressures.
To slightly adept one of Sabine's statements Dave was criticizing:

"I don't trust youtubers."